A Case Report of a Severely Immunocompromised Patient with Clinically Amyopathic Dermatomyositis-related ILD: Is CMV-prevention Indicated?

Abstract

We herein report a case of a 59-year old female with rapidly progressive interstitial lung disease due to antiMDA-5 positive clinically amyopathic dermatomyositis. Despite initial response to a combination high dose immunosuppressive treatment, her respiratory condition deteriorated and she was screened for urgent lung transplantation. During screening an active CMV-infection was revealed, which made her ineligible for the procedure. Unfortunately, despite CMV treatment, the patient died due to her pulmonary condition. Since more aggressive immunosuppressive regimens increase risk of viral reactivation, and after reviewing the literature, we debated if in analogue with solid organ transplantation, CMV prevention or monitoring should be applied to optimize clinical outcome. *Corresponding author: Johanna Kwakkel-van Erp, Department of Pulmonology, University Hospital Antwerpen (UZA), Edegem, Belgium, Tel: +32468040187, Fax: +3238214447; E-mail: Johanna.Kwakkel-vanErp@uza.be Received November 08, 2018; Accepted November 14, 2018; Published November 21, 2018 Citation: Bernhard AE, Leavis HL, Verduyn Luynel FM, Mohamed Hoesein FAA, Voortman M, et al. (2018) A Case Report of a Severely Immunocompromised Patient with Clinically Amyopathic Dermatomyositis-related ILD: Is CMV-prevention Indicated?. J Pulm Respir Med 8: 480. doi: 10.4172/2161-105X.1000480 Copyright: ©2018 Bernhard AE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.