Evaluation of Lactic Acid Bacteria with Anti-Fatigue Effects

Abstract

This study was to evaluate the anti-fatigue effects of lactic acid bacteria (LAB) produced by Grape King Bio Ltd. In the experiment, 35 male ICR mice were randomly divided into 7 groups (n = 5): control (Vehicle), LAB GKJ1, GKK1, GKK3, GKK4, GKEX, and GKY5. Different LAB strains were continuously fed for about 40 days. The forelimb grip and the exercise exhaustion were analyzed, as well as the serum lactate and blood urea nitrogen (BUN) after exercise were monitored respectively during the 29 th to 39 th day of the experiment. The results showed that, among the tested LAB strains, Lactiplantibacillus plantarum GKK1 and Levilactobacillus brevis GKEX significantly improved the forelimb grip, time to exhaustion, and maintained lower serum lactate and BUN respectively after exercise when compared to the vehicle. In addition, they significantly increased the glycogen in the liver and muscles. From the above results, L. plantarum GKK1 and L. brevis GKEX have the potential to improve exercise endurance and reduce exercise fatigue indicators, which can be applied to the development of health care products related to exercise promotion.