Interference caused by anti-streptavidin antibodies in a parathyroid hormone assay; a case report

B. Trautz, T. Negele
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Abstract

Endogenous antibodies can lead to test interference in streptavidin-biotin based laboratory assays, such as thyroid function tests or parathyroid hormone (PTH) levels. We report about a patient, who presented for thyroid surgery, showing undetectable PTH levels despite normocalcaemia in internally assessed preoperative laboratory work. Previously, anti-streptavidin antibodies were detected in the patient’s blood and normal PTH levels could be measured in a streptavidin-free assay. To our knowledge this is the first reported case of a clinically relevant PTH test interference due to endogenous anti-streptavidin antibodies, thus complicating the evaluation of postoperative hypoparathyroidism.
抗链霉亲和素抗体对甲状旁腺激素测定的干扰病例报告
内源性抗体可导致基于链霉亲和素的实验室检测干扰,如甲状腺功能测试或甲状旁腺激素(PTH)水平。我们报告一个病人,谁提出甲状腺手术,显示未检测到甲状旁腺激素水平,尽管在内部评估术前实验室工作正常血钙。以前,抗链霉亲和素抗体是在患者血液中检测到的,正常的甲状旁腺素水平可以通过无链霉亲和素测定来测量。据我们所知,这是第一例因内源性抗链霉亲和素抗体而导致临床相关的甲状旁腺素测试干扰的报道,从而使术后甲状旁腺功能低下的评估复杂化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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