Post-Mortem Analysis of Diazinon and its major Metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine, in a Case of Fatal Diazinon Ingestion

Q4 Social Sciences
Ibraheem M. Attafi, Magbool E. Oraiby, Mohsen M. Fageeh, Ghassam A. Shaikhain, Mohammed Y. Albeishy, Ibrahim A. Khardali, Mohammed A. Hakami
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Abstract

This case report describes a detection and quantitation method for diazinon and its major metabolite, 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMHP), in postmortem blood and tissue samples from a fatal case of diazinon ingestion. Diazinon and IMHP were extracted from postmortem samples with a liquid/liquid method and analyzed by gas chromatography mass spectrometry (GC/MS). By comparing to diazinon standard and matching the retention time, diazinon was detected in two visceral organs, the stomach (0.89 μg/g) and the small intestine (8.80 μg/g). The highest level of diazinon was detected in the small intestine (8.80 μg/g), whereas the highest amount of IMHP was noted in the kidney (0.84 Area %) and bladder (0.75 Area %). In conclusion, determination of IMHP in postmortem samples could be used as an indicator for diazinon exposure, especially in the case of delayed death; whereas, the small intestine could be the best source of sample in diazinon assessment in cases of fatal diazinon ingestion.
致死性摄入二嗪农病例中二嗪农及其主要代谢物2-异丙基-4-甲基-6-羟基嘧啶的尸检分析
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来源期刊
CiteScore
0.30
自引率
0.00%
发文量
8
审稿时长
12 weeks
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