Clinical efficacy of two forms of intravenous iron--saccharated ferric oxide and cideferron--for iron deficiency anemia.

T. Araki, M. Takaai, A. Miyazaki, S. Ohshima, T. Shibamiya, T. Nakamura, K. Yamamoto
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引用次数: 2

Abstract

Over 90% of iron deficiency anemia cases are due to iron deficiency associated with depletion of stored iron or inadequate intake. Parenteral iron supplementation is an important part of the management of anemia, and some kinds of intravenous iron are used. However, few studies have evaluated the clinical efficacy of these drugs. The purpose of this study was to compare and assess the clinical efficacy of two types of intravenous iron injection, saccharated ferric oxide (SFO) and cideferron (CF). Medical records were obtained for 91 unrelated Japanese anemia patients treated with SFO (n = 37) or CF (n = 54) from May 2005 to May 2010 at Gunma University Hospital. Patients treated with blood transfusion, erythropoietin or oral iron were excluded. Hemoglobin (Hb) values measured on day 0, 7 and 14 were used to assess the efficacy of intravenous irons. A significant increase was observed in the mean Hb value by day 14 of administration in both the CF group and SFO group, and the mean Hb increase due to administration of CF for 7 days was comparable to that of SFO for 14 days. Age and sex did not affect improvement of Hb value. CF is fast acting and highly effective compared with SFO for the treatment of iron deficiency anemia. The use of CF may shorten a therapeutic period for iron deficiency anemia, and CF may be feasible for reducing the hospitalization period.
糖氧化铁和西铁铁两种形式静脉补铁治疗缺铁性贫血的临床疗效观察。
超过90%的缺铁性贫血病例是由于与储存的铁耗尽或摄入不足有关的缺铁。肠外补铁是贫血治疗的重要组成部分,一些类型的静脉补铁被使用。然而,很少有研究评估这些药物的临床疗效。本研究的目的是比较和评价糖氧化铁(SFO)和西铁铁(CF)两种静脉注射铁的临床疗效。获得2005年5月至2010年5月在群马大学医院接受SFO (n = 37)或CF (n = 54)治疗的91例无相关性日本贫血患者的医疗记录。排除输血、促红细胞生成素或口服铁治疗的患者。第0天、第7天和第14天的血红蛋白(Hb)值用于评估静脉注射铁剂的疗效。在给药后第14天,CF组和SFO组的平均Hb值均显著升高,并且CF给药7天的平均Hb升高与SFO给药14天的平均Hb升高相当。年龄和性别对Hb值的改善没有影响。与SFO相比,CF治疗缺铁性贫血快速有效。使用CF可缩短缺铁性贫血的治疗期,CF可缩短住院时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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