Bicarbonate‐rich fluid secretion predicted by a computational model of guinea‐pig pancreatic duct epithelium

M. Yamaguchi, M. Steward, Kieran Smallbone, Y. Sohma, A. Yamamoto, S. Ko, T. Kondo, H. Ishiguro
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引用次数: 20

Abstract

The ductal system of the pancreas secretes large volumes of alkaline fluid containing HCO3− concentrations as high as 140 mm during hormonal stimulation. A computational model has been constructed to explore the underlying ion transport mechanisms. Parameters were estimated by fitting the model to experimental data from guinea‐pig pancreatic ducts. The model was readily able to secrete 140 mm HCO3−. Its capacity to do so was not dependent upon special properties of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channels and solute carrier family 26 member A6 (SLC26A6) anion exchangers. We conclude that the main requirement for secreting high HCO3− concentrations is to minimize the secretion of Cl− ions. These findings help to clarify the mechanism responsible for pancreatic HCO3− secretion, a vital process that prevents the formation of protein plugs and viscous mucus in the ducts, which could otherwise lead to pancreatic disease.
用豚鼠胰管上皮计算模型预测富碳酸氢盐液体分泌
在激素刺激下,胰腺导管系统分泌大量含HCO3−浓度高达140 mm的碱性液体。已经建立了一个计算模型来探索潜在的离子传输机制。通过将模型与豚鼠胰管的实验数据拟合来估计参数。该模型能够分泌140 mm的HCO3−。它这样做的能力并不依赖于囊性纤维化跨膜电导调节剂(CFTR)阴离子通道和溶质载体家族26成员A6 (SLC26A6)阴离子交换剂的特殊性质。我们得出结论,分泌高HCO3−浓度的主要要求是尽量减少Cl−离子的分泌。这些发现有助于阐明胰腺HCO3−分泌的机制,这是一个重要的过程,可以防止在导管中形成蛋白塞和粘稠粘液,否则可能导致胰腺疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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