ENHANCEMENT OF ANTIBACTERIAL EFFECTIVENESS OF AMOXICILLIN TRIHYDRATE AND AMPICILLIN-SULBACTAM

Abstract

The enhancement studies of antibacterial activity of antibotics is an important issue because of the increasing in multiple antibiotic resistant pathojen microorganisms. In this study, the synergistic effects of Punica granatum L. acetone fruit peel extract and antibiotics (Ampicillin-Sulbactam and Amoxicillin trihydrate) combinations were investigated. Disk diffusion method was used for determination of the synergistic effect. Pomegranate acetone fruit peel extract and Amoxicillin trihydrate combination showed synergistic effect against Escherichia coli, Stapylococcus aureus, Stapylococcus epidermidis, Salmonella typhimurium, Enterococcus faecalis, and Bacillus subtilis. Besides, the combination of P. granatum acetone fruit peel extract and Ampicillin-Sulbactam exhibited synergistic effect against S. epidermidis, E. faecalis, and B. subtilis. According to the results of this study, Punica granatum acetone fruit peel extract highly improved the antibacterial efficacy of Amoxicillin trihydrate and Ampicillin-Sulbactam.