Low-Cost Three-Dimensionally -Printed Inverted Plug and Play Optical Instrument for Microfluidic Imaging

IF 1.5 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Micro & Nano Letters Pub Date : 2023-05-16 DOI:10.3390/micro3020036

Denislav Markov, Emil Grigorov, B. Kirov, J. Denev, V. Galabov, M. Marinov

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引用次数: 0

Abstract

Microfluidics, also known as lab-on-a-chip or micro total analysis systems, can precisely regulate and manipulate micro-sized fluids. They have great potential in biology, chemistry, and medicine, as well as other fields of science. By definition, microfluidic devices operate with small-volume samples and small reactant quantities, which renders them both efficient and affordable. However, such small objects have very demanding requirements for the utilized optical detection system. Due to the specifics of those devices, monitoring the results of experiments is carried out with commercial inverted optical microscopes. Unfortunately, that type of optical device is still expensive. In this article, we present a truly functional, inexpensive, standalone, three-dimensionally printed, and inverted microscope, including the design, engineering, and manufacturing process and some of the experiments that have been conducted with it. Finally, we summarize the advantages of this three-dimensionally printed microscope (including the total fabrication costs) and the future improvements that will be introduced to it.

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用于微流体成像的低成本三维印刷倒置即插即用光学仪器

微流体，也被称为芯片实验室或微全分析系统，可以精确地调节和操纵微尺寸的流体。他们在生物、化学、医学以及其他科学领域都有很大的潜力。根据定义，微流控装置在小体积样品和小反应物量下运行，这使得它们既高效又经济。然而，这样的小物体对所使用的光学检测系统有着非常苛刻的要求。由于这些设备的特殊性，监测实验结果是用商用倒置光学显微镜进行的。不幸的是，这种光学设备仍然很昂贵。在这篇文章中，我们提出了一个真正的功能，廉价的，独立的，三维打印和倒置显微镜，包括设计，工程，制造过程和一些实验已经进行了它。最后，我们总结了这种三维打印显微镜的优点(包括总制造成本)和未来的改进，将介绍给它。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micro & Nano Letters 工程技术-材料科学：综合

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.8 months

期刊介绍： Micro & Nano Letters offers express online publication of short research papers containing the latest advances in miniature and ultraminiature structures and systems. With an average of six weeks to decision, and publication online in advance of each issue, Micro & Nano Letters offers a rapid route for the international dissemination of high quality research findings from both the micro and nano communities. Scope Micro & Nano Letters offers express online publication of short research papers containing the latest advances in micro and nano-scale science, engineering and technology, with at least one dimension ranging from micrometers to nanometers. Micro & Nano Letters offers readers high-quality original research from both the micro and nano communities, and the materials and devices communities. Bridging this gap between materials science and micro and nano-scale devices, Micro & Nano Letters addresses issues in the disciplines of engineering, physical, chemical, and biological science. It places particular emphasis on cross-disciplinary activities and applications. Typical topics include: Micro and nanostructures for the device communities MEMS and NEMS Modelling, simulation and realisation of micro and nanoscale structures, devices and systems, with comparisons to experimental data Synthesis and processing Micro and nano-photonics Molecular machines, circuits and self-assembly Organic and inorganic micro and nanostructures Micro and nano-fluidics