SÍNDROME DE STEVENS JOHNSON ASSOCIADA AO USO DE FENITOÍNA: UM RELATO DE CASO

IF 2.7 3区生物学 Q3 CELL BIOLOGY

Nucleus Pub Date : 2021-04-30 DOI:10.3738/1982.2278.3892

Mariana Rossi Corregliano, Stella De Souza Martins, Luelen da Silva Pinto

引用次数: 0

Abstract

A sindrome de Stevens-Johnson e uma entidade dermatologica rara e potencialmente fatal, que se caracteriza por um processo de necrose dos queratinocitos e consequente descolamento da epiderme. A maioria dos casos ocorre devido ao uso de farmacos, principalmente beta-lactâmicos, anticonvulsivantes aromaticos e alopurinol. O diagnostico e basicamente clinico e o tratamento e focado na retirada do agente causador associado a suporte clinico. Este trabalho tem como objetivo principal contribuir para a difusao de conhecimento medico a respeito da sindrome em questao, atraves da descricao de um caso clinico de paciente internada na Santa Casa de Franca no ano de 2019.

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史蒂文斯约翰逊综合征与苯妥英的使用:一个病例报告

史蒂文斯-约翰逊综合征是一种罕见的、可能致命的皮肤病，其特征是角化细胞坏死和表皮脱落。大多数病例是由于使用药物，主要是β -内酰胺类药物、芳香抗惊厥药和别嘌呤醇。诊断和治疗主要是临床的，重点是去除与临床支持相关的病原体。这项工作的主要目标是通过描述2019年在圣卡萨·德·弗兰卡住院的一个临床病例，促进有关该综合征的医学知识的传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nucleus CELL BIOLOGY-

CiteScore

5.60

自引率

5.40%

发文量

审稿时长

13 weeks

期刊介绍： Nucleus is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Aims & Scope: The eukaryotic cell nucleus is more than a storage organelle for genomic DNA. It is involved in critical steps of cell signaling and gene regulation, as well as the maintenance of genome stability, including DNA replication and DNA damage repair. These activities heavily depend on the spatial and temporal “functional” organization of the nucleus and its integration into the complex meshwork of cellular scaffolding. Nucleus provides a platform for presenting and discussing cutting-edge research on all aspects of biology of the cell nucleus. It brings together a multidisciplinary community of scientists working in the areas of: • Nuclear structure and dynamics • Subnuclear organelles • Chromatin organization • Nuclear transport • DNA replication and DNA damage repair • Gene expression and RNA processing • Nucleus in signaling and development Nucleus offers a variety of paper formats including: • Original Research articles • Short Reports • Reviews • Commentaries • Extra Views • Methods manuscripts.