Food cue reward salience does not explain Hyperphagia in adolescents with Prader-Willi syndrome.

IF 1.6 4区心理学 Q3 PSYCHOLOGY

Developmental Neuropsychology Pub Date : 2023-11-06 DOI:10.2139/ssrn.4227656

Menton M. Deweese, E. Roof, A. Key

引用次数: 0

Abstract

Prader-Willi Syndrome (PWS) is characterized by hyperphagia, an extreme and persistent hunger that emerges in early childhood. We used event-related potentials (ERPs) to objectively investigate brain responses to low- and high-calorie foods, animals, and household objects in 20 satiated adolescents with PWS. Late Positive Potential (LPP) responses to food images did not differ from non-food images. Rather, we observed larger ERPs to high-calorie foods relative to animal images (p=.001) in an earlier time window. These responses correlated with greater severity of hyperphagia (p = .01). Thus, hyperphagia associated with PWS may be due to altered satiety regulation rather than increased motivational salience.

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食物提示奖励的显著性并不能解释Prader-Willi综合征青少年的贪食症。

普瑞德-威利综合征(PWS)的特征是嗜食，一种在儿童早期出现的极端和持续的饥饿。我们使用事件相关电位(ERPs)客观地研究了20名患有PWS的饱腹青少年对低热量和高热量食物、动物和家用物品的大脑反应。晚期正电位(LPP)对食物图像的反应与对非食物图像的反应没有差异。相反，我们观察到，在较早的时间窗口中，相对于动物图像，高热量食物的erp更大(p= 0.001)。这些反应与更严重的贪食相关(p = 0.01)。因此，与PWS相关的贪食可能是由于饱腹调节的改变而不是动机显著性的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Neuropsychology 医学-心理学

CiteScore

2.80

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Devoted to exploring relationships between brain and behavior across the life span, Developmental Neuropsychology publishes scholarly papers on the appearance and development of behavioral functions, such as language, perception, and social, motivational and cognitive processes as they relate to brain functions and structures. Appropriate subjects include studies of changes in cognitive function—brain structure relationships across a time period, early cognitive behaviors in normal and brain-damaged children, plasticity and recovery of function after early brain damage, the development of complex cognitive and motor skills, and specific and nonspecific disturbances, such as learning disabilities, mental retardation, schizophrenia, stuttering, and developmental aphasia. In the gerontologic areas, relevant subjects include neuropsychological analyses of normal age-related changes in brain and behavioral functions, such as sensory, motor, cognitive, and adaptive abilities; studies of age-related diseases of the nervous system; and recovery of function in later life. Empirical studies, research reviews, case reports, critical commentaries, and book reviews are featured in each issue. By publishing both basic and clinical studies of the developing and aging brain, the journal encourages additional scholarly work that advances understanding of the field of lifespan developmental neuropsychology.