Infection History and Current Coinfection With Schistosoma mansoni Decreases Plasmodium Species Intensities in Preschool Children in Uganda.

IF 2.3 3区社会学 Q1 INTERNATIONAL RELATIONS

Journal of International Relations and Development Pub Date : 2022-06-15 DOI:10.1093/infdis/jiac072

Daniel McDowell, Lisa Hurt, Narcis B Kabatereine, John Russell Stothard, Joanne Lello

引用次数: 0

Abstract

Malaria-schistosomiasis coinfections are common in sub-Saharan Africa but studies present equivocal results regarding the interspecific relationships between these parasites. Through mixed-model analyses of a dataset of Ugandan preschool children, we explore how current coinfection and prior infection with either Schistosoma mansoni or Plasmodium species alter subsequent Plasmodium intensity, Plasmodium risk, and S mansoni risk. Coinfection and prior infections with S mansoni were associated with reduced Plasmodium intensity, moderated by prior Plasmodium infections, wealth, and host age. Future work should assess whether these interactions impact host health and parasite control efficacy in this vulnerable age group.

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乌干达学龄前儿童的曼氏血吸虫感染史和目前的合并感染会降低疟原虫的种群密度。

疟疾-血吸虫病合并感染在撒哈拉以南非洲地区很常见，但有关这些寄生虫之间种间关系的研究结果并不一致。通过对乌干达学龄前儿童数据集进行混合模型分析，我们探讨了当前合并感染和先前感染曼氏血吸虫或疟原虫如何改变随后的疟原虫强度、疟原虫风险和曼氏血吸虫风险。曼氏血吸虫的合并感染和既往感染与疟原虫强度的降低有关，并受既往疟原虫感染、财富和宿主年龄的影响。未来的工作应评估这些相互作用是否会影响这一脆弱年龄组的宿主健康和寄生虫控制效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Relations and Development Multiple-

CiteScore

3.60

自引率

5.90%

发文量

期刊介绍： JIRD is an independent and internationally peer-reviewed journal in international relations and international political economy. It publishes articles on contemporary world politics and the global political economy from a variety of methodologies and approaches. The journal, whose history goes back to 1984, has been established to encourage scholarly publications by authors coming from Central/Eastern Europe. Open to all scholars since its refoundation in the late 1990s, yet keeping this initial aim, it applied a rigorous peer-review system and became the official journal of the Central and East European International Studies Association (CEEISA). JIRD seeks original manuscripts that provide theoretically informed empirical analyses of issues in international relations and international political economy, as well as original theoretical or conceptual analyses.