Evaluation of Prepubertal Patients with Suspected Neurosecretory Dysfunction of Growth Hormone Secretion: Diagnostic Steps and Treatment Response

Adv. Artif. Neural Syst. Pub Date : 2016-08-19 DOI:10.1155/2017/9256043

Carmen Sydlik, C. Weißenbacher, J. Roeb, S. B. Pozza, H. Schmidt

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Abstract

Background and Aims. Existence and diagnostic procedures of neurosecretory dysfunction of growth hormone (NSD) are still a matter of debate. The aim of our study was (a) to find out if prediagnostic auxological and laboratory data could serve as an indicator for pathologic and normal spontaneous GH-secretion and (b) to evaluate the response to GH-therapy in NSD-patients. Methods. Of 90 children (unicentric study) with normal response to GH-stimulation tests, in whom 12-hour night profiles for GH-secretion were performed, 49 were diagnosed with NSD (NSD group). Their auxologic data, IGF-I/IGFBP3-levels as well as the night profiles, were analysed and compared to those of the non-NSD group. Additionally, follow-up auxological data of the GH-treated NSD-patients were collected. Results. Prediagnostic auxologic and laboratory data did not differ between the two groups. Instead, for all analysed criteria of spontaneous GH-secretion (number of peaks, maximal and mean secretion) a significant difference was found. Children with NSD showed a good response to GH-treatment after 1 (H-SDS

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青春期前疑似生长激素分泌神经分泌功能障碍患者的评价:诊断步骤和治疗反应

背景和目的。生长激素神经分泌功能障碍(NSD)的存在和诊断方法仍然是一个争论的问题。我们研究的目的是(a)发现诊断前的生理和实验室数据是否可以作为病理和正常自发gh分泌的指标，(b)评估nsd患者对gh治疗的反应。方法。在90名对gh刺激试验反应正常的儿童(单中心研究)中，进行了12小时夜间gh分泌谱分析，其中49名被诊断为NSD (NSD组)。他们的生理性数据，IGF-I/ igfbp3水平以及夜间特征，被分析并与非nsd组进行比较。此外，还收集了gh治疗的nsd患者的随访生成学数据。结果。两组的诊断前形态学和实验室数据没有差异。相反，对于所有自发gh分泌的分析标准(峰数，最大值和平均分泌)，发现显着差异。NSD患儿在1 (H-SDS)后对gh治疗反应良好

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Adv. Artif. Neural Syst.

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