Low-grade glial tumors: The experience of an oncology hospital in Türkiye

IF 0.3 4区医学 Q4 Medicine

Acta Medica Mediterranea Pub Date : 2023-06-30 DOI:10.32552/2023.actamedica.899

S. Ceylan, N. Kertmen, G. Yazici, A. Kars

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Abstract

Objective: Several factors are important in the prognosis of low grade gliomas, besides genetic changes. The present study aims to examine the effect of other factors on prognosis except for genetic changes in low grade gliomas (LGGs). Materials and Methods: Patients diagnosed with “brain malignant neoplasm” who were referred to Hacettepe University Oncology Hospital were screened. Among these patients, 148 patients with a supratentorial low grade gliomas whose data are completely available were included. Patients were followed for at least five years after diagnosis or death within this period. Results: Mean age of diagnosis was 36.2±10.7 years, and 52.7% of patients (n=78) were females, Most common subtype was oligodendroglioma (n=86, 58.1%). Sixty-two of patients relapsed (41.9%). The 5-year mortality rate was 35.1% (n=52). Kaplan-Meier analysis of the variables, the only difference was between histopathological subtypes (p=0.03). Astrocytoma histology was related to wporse prognosis. Cox regression analysis of factors affecting 5-year mortality, advancing age (HR: 1.03, 95% CI: 1.00-1.06, p=0.03), astrocytoma (HR: 2.59, 95% CI: 1.35-4.98, p=0.004) and oligoastrocytoma (HR: 2.13, 95% CI: 1.02-4.43, p=0.04) were identified to increase the mortality risk. Conclusion: The age of the patients and the histopathologic subtype of the tumor must be taken into consideration during the follow-up and treatment of low grade gliomas.

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低级别神经胶质肿瘤:台湾一家肿瘤医院的经验

目的:低级别胶质瘤的预后除遗传改变外，还有几个重要因素。本研究旨在探讨除遗传改变外其他因素对低级别胶质瘤(LGGs)预后的影响。材料与方法:对转入Hacettepe大学肿瘤医院诊断为“脑恶性肿瘤”的患者进行筛查。在这些患者中，148例幕上低级别胶质瘤患者的资料完全可用。患者在确诊或死亡后至少随访5年。结果:平均诊断年龄为36.2±10.7岁，女性占52.7% (n=78)，少突胶质细胞瘤最常见亚型(n=86, 58.1%)。62例复发(41.9%)。5年死亡率为35.1% (n=52)。Kaplan-Meier分析的变量，唯一的差异是在组织病理学亚型之间(p=0.03)。星形细胞瘤组织学与预后不良有关。Cox回归分析发现，年龄增大(HR: 1.03, 95% CI: 1.00-1.06, p=0.03)、星形细胞瘤(HR: 2.59, 95% CI: 1.35-4.98, p=0.004)和少星形细胞瘤(HR: 2.13, 95% CI: 1.02-4.43, p=0.04)是增加5年死亡率的因素。结论:低级别胶质瘤的随访和治疗必须考虑患者的年龄和肿瘤的组织病理学亚型。

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来源期刊

Acta Medica Mediterranea 医学-医学：内科

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Medica Mediterranea is an indipendent, international, English-language, peer-reviewed journal, online and open-access, designed for internists and phisicians. The journal publishes a variety of manuscript types, including review articles, original research, case reports and letters to the editor.