Numerical Investigation of the Hemodynamic Environment Change in Patient-Specific Intracranial Aneurysm with Progressive Stenosis in Unilateral Internal Carotid Artery

Q4 Biochemistry, Genetics and Molecular Biology

Molecular & Cellular Biomechanics Pub Date : 2019-02-21 DOI:10.32604/MCB.2019.05730

Guangyu Zhu, Yuan Wei, Q. Yuan, Ge Yan, Jian Yang

引用次数: 4

Abstract

Intracranial aneurysm (IAs) is a frequently localized cerebral vascular disorder of an overall prevalence of 5-8% [Cebral (2013)]. Subarachnoid hemorrhage (SAH) caused by IAs rupture is one of the major causes of mortality and morbidity in the modern world. Local hemodynamic characteristics played important roles in the rupture of IAs and has been studied extensively from different perspectives [Liu (2015); Brinjikji (2017)]. However, the influence of progressive cerebral stenosis on the hemodynamic of the distal cerebral aneurysm is yet to be further investigated. In this study, a set of patient-specific computational fluid dynamics (CFD) simulations were performed to investigate the impact of internal carotid artery (ICA) stenosis growing on the hemodynamic environments in an anterior communicating artery aneurysm (ACoAA).

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单侧颈内动脉进行性狭窄患者颅内动脉瘤血流动力学环境变化的数值研究

颅内动脉瘤(IAs)是一种常见的局部脑血管疾病，总体患病率为5-8% [brain(2013)]。蛛网膜下腔出血(SAH)引起的破裂引起的死亡和发病率的主要原因之一，在现代世界。局部血流动力学特征在IAs破裂中发挥了重要作用，并从不同角度进行了广泛的研究[Liu (2015);Brinjikji(2017)]。然而，进行性脑狭窄对脑远端动脉瘤血流动力学的影响还有待进一步研究。本研究通过一组患者特异性计算流体动力学(CFD)模拟来研究颈内动脉(ICA)狭窄对前交通动脉瘤(ACoAA)血流动力学环境的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular & Cellular Biomechanics CELL BIOLOGYENGINEERING, BIOMEDICAL&-ENGINEERING, BIOMEDICAL

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications.