A review on biogenic silver nanoparticles as efficient and effective antidiabetic agents

Functional Food Science Pub Date : 2023-07-14 DOI:10.31989/ffs.v3i7.1119

M. Wahab, S. Janaswamy

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Abstract

The frontiers of nanomedicine are consistently being challenged by the gradually expanding knowledge of the properties of nanoparticles. Toward this end, biogenic synthesis of silver nanoparticles utilizing natural compounds in plants as reducing and capping agents grabbed considerable attention, in lieu of synthetic hazardous physical and chemical techniques. Green synthesis of silver nanoparticles (AgNPs) has proven safe and effective in treating type 2 diabetes mellitus. Currently, biogenic silver nanoparticles have gained importance as safe and efficient antiglycation agents. Therapeutic strategies by employing nanomedicines from natural sources have been initiated to end the limitations of currently available medications for the treatment of various disorders, including diabetes, Alzheimer’s, cancer, and hepatitis. This article highlights the medicinal efficacy of silver nanoparticles synthesized from different plant extracts for their antidiabetic potential characterized through various in vivo and in vitro assays and unravels their unique properties. This article also focuses on the signaling pathways linked to type II diabetes and the demand for nanomedicine and greener pathways for future pharmacological industries.Keywords: Biogenic silver nanoparticles, antioxidant, Type 2 Diabetes Mellitus (T2DM), α-glucosidase assay, α-amylase assay

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生物源性纳米银作为高效降糖药的研究进展

纳米医学的前沿不断受到挑战，逐渐扩大的知识纳米颗粒的性质。为此，利用植物中的天然化合物作为还原和封盖剂的生物合成纳米银引起了相当大的关注，取代了危险的物理和化学合成技术。绿色合成银纳米颗粒(AgNPs)治疗2型糖尿病已被证明安全有效。目前，生物纳米银作为一种安全有效的抗糖化药物已经得到了越来越多的重视。利用天然来源的纳米药物的治疗策略已经开始，以结束目前可用于治疗各种疾病的药物的局限性，包括糖尿病、阿尔茨海默氏症、癌症和肝炎。本文重点介绍了由不同植物提取物合成的银纳米颗粒的药物功效，并通过各种体内和体外实验对其抗糖尿病潜能进行了表征，揭示了其独特的性质。本文还关注了与II型糖尿病相关的信号通路，以及未来药理学行业对纳米医学和绿色通路的需求。关键词:纳米银，抗氧化剂，2型糖尿病，α-葡萄糖苷酶测定，α-淀粉酶测定

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来源期刊

Functional Food Science

CiteScore

3.20

自引率

0.00%

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