A review on biogenic silver nanoparticles as efficient and effective antidiabetic agents

Abstract

The frontiers of nanomedicine are consistently being challenged by the gradually expanding knowledge of the properties of nanoparticles. Toward this end, biogenic synthesis of silver nanoparticles utilizing natural compounds in plants as reducing and capping agents grabbed considerable attention, in lieu of synthetic hazardous physical and chemical techniques. Green synthesis of silver nanoparticles (AgNPs) has proven safe and effective in treating type 2 diabetes mellitus. Currently, biogenic silver nanoparticles have gained importance as safe and efficient antiglycation agents. Therapeutic strategies by employing nanomedicines from natural sources have been initiated to end the limitations of currently available medications for the treatment of various disorders, including diabetes, Alzheimer’s, cancer, and hepatitis. This article highlights the medicinal efficacy of silver nanoparticles synthesized from different plant extracts for their antidiabetic potential characterized through various in vivo and in vitro assays and unravels their unique properties. This article also focuses on the signaling pathways linked to type II diabetes and the demand for nanomedicine and greener pathways for future pharmacological industries.Keywords: Biogenic silver nanoparticles, antioxidant, Type 2 Diabetes Mellitus (T2DM), α-glucosidase assay, α-amylase assay