Hypoglycemia and neurological outcome in neonates: A retrospective study in a tertiary care hospital in Henan, China

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Mohammad Ansari, Xiao Li, Xiao-li Zhang, K. Du, Yan Dong, Xiaoli Li, Qiliang Guo, L. Gan, T. Jia
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Abstract

This is a retrospective study done on 170 children, aged 3 to 5 years, who were delivered in the third affiliated hospital of Zhengzhou university, Henan, China between Jan 2019 to Dec 2020. With the help of hospital records, a systematic detection of hypoglycemia (<2.2 mmol/L or 40 mg/dL) was carried out in the study population from birth to 28 days after birth. Main outcomes were a compiled neurological or neurodevelopmental outcome; any developmental delay; motor developmental delay; and cognitive developmental delay. For analysis, the study population was divided into two groups: one group consisted of children who suffered from 5 or more episodes of hypoglycemia in neonatal period (n=42) and the second group consisted those who suffered with less than 5 episodes (n=128). We noted that the group having 5 or more hypoglycemic episodes had a higher proportion of premature or small for date children than the other group (76.2% Vs 60.9%), and the difference is statistically significant. In adjusted regression analyses, the odds ratio (OR) of any neurological or neurodevelopmental outcome was 1.48 (95% confidence interval: 1.17–1.88) in group with 5 or more hypoglycemic episodes as compared to the other group. The adjusted risk of any developmental delay was more than doubled (OR 2.53 [1.71–3.73]), the adjusted risk of motor developmental delay was almost doubled (OR: 1.91 [1.06–3.44]) and the adjusted risk of cognitive developmental delay was almost tripled (OR 2.85 [1.70–4.76]) in the group that had more than 5 hypoglycemic episodes in neonatal period.
低血糖和新生儿神经预后:中国河南一家三级医院的回顾性研究
本研究对2019年1月至2020年12月在中国河南省郑州大学第三附属医院出生的170名3 - 5岁儿童进行回顾性研究。在医院记录的帮助下,对研究人群从出生到出生后28天进行低血糖(<2.2 mmol/L或40 mg/dL)的系统检测。主要结局是汇编的神经学或神经发育结局;任何发育迟缓;运动发育迟缓;认知发育迟缓。为了进行分析,研究人群被分为两组:一组包括在新生儿期发生5次或5次以上低血糖发作的儿童(n=42),第二组包括发生5次以下低血糖发作的儿童(n=128)。我们注意到,有5次及以上低血糖发作的组早产儿和小男婴的比例高于另一组(76.2% Vs 60.9%),差异有统计学意义。在校正回归分析中,与其他组相比,5次或5次以上低血糖发作组的任何神经或神经发育结局的优势比(OR)为1.48(95%可信区间:1.17-1.88)。新生儿低血糖发作5次以上组,任何发育迟缓的调整风险增加一倍以上(OR为2.53[1.71-3.73]),运动发育迟缓的调整风险几乎增加一倍(OR为1.91[1.06-3.44]),认知发育迟缓的调整风险几乎增加两倍(OR为2.85[1.70-4.76])。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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