Association the study of between CPEB1 (rs230846 C>T) gene polymorphism and azoospermia/ severe oligospermia

Abstract

BACKGROUND AND OBJECTIVE: : CPEB1 gene plays a significant role during gametogenesis. Due to remain unclear many causes of male infertility, we aimed to evaluate the association between of CPEB1 rs2303846 gene polymorphism with the risk of men with idiopathic azoospermia/ severe oligospermia. METHODS: The present study is a case-control investigation, were performed on 100 peripheral blood samples of men with idiopathic azoospermia/ severe oligozoospermia and 100 blood samples of healthy men, who were referred to department of infertility and sterility of Tabriz Al-Zahra hospital from 2015 to 2017. The PCR-RFLP method was used to determine the frequency of genotypes and then compared the relationship between polymorphism and clinical parameters. FINDINGS: The genotypes frequency of CEBP1 gene polymorphism CT+TT/CC did not show a statistically significant difference between groups (P=0.395, OR=1.273; CI=0.730-2.220). In addition, no significant correlation was found between genotypes and FSC, MSC and SMI clinical parameters (p<0.05). CONCLUSION: Findings revealed that CEBP1 rs2303846 gene polymorphism cannot to be considered as a risk factor for idiopathic azoospermia/ severe oligospermia men.