An Ambiguous Rash in an 11-Year-Old Boy

Daniel R. O’Neill, Rachel A. Reedy
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Abstract

The varicella zoster virus is known for two distinct disease states, the primary varicella zoster virus and herpes zoster. Children who are vaccinated for varicella have a lower incidence of developing herpes zoster than those who have acquired the varicella virus. Regardless, vaccinated children are still at risk for developing herpes zoster and the diagnosis should be considered in patients with a clinical presentation of vesicular and erythematous lesions. An 11-year-old boy, with no significant past medical history, presented to his primary care physician for a rash on his lower back. A thorough history of possible contact exposures was ruled out and further review showed that the boy was up to date on all vaccines. The combination of his physical symptoms and appearance of the rash prompted a culture to be sent to the lab. These results returned positive for varicella zoster DNA on the corresponding polymerase chain reaction (PCR) and proper treatment was initiated. The manifestation of herpes zoster can vary in appearance and does not always present in a standard dermatomal pattern. When clinical diagnosis seems vague, pattern recognition of the distinct vesicular rash shared with a high index of suspicion due to associated symptoms should prompt the culturing of a vesicle for diagnosis of herpes zoster via DNA PCR. Early detection will help hasten appropriate treatment and education to reduce further spread of the virus. Int J Clin Pediatr. 2019;8(1):19-21 doi: https://doi.org/10.14740/ijcp334
一名11岁男孩的模糊皮疹
水痘带状疱疹病毒以两种不同的疾病状态而闻名,原发性水痘带状疱疹病毒和带状疱疹。接种水痘疫苗的儿童患带状疱疹的几率比接种水痘病毒的儿童低。无论如何,接种疫苗的儿童仍有发生带状疱疹的风险,在临床表现为水疱和红斑病变的患者中应考虑诊断。一名11岁男孩,无明显既往病史,因下背部皮疹向初级保健医生就诊。彻底排除了可能的接触史,进一步审查表明,该男孩已及时接种了所有疫苗。他的身体症状和皮疹外观的结合促使将培养物送到实验室。这些结果在相应的聚合酶链反应(PCR)上返回水痘带状疱疹DNA阳性,并开始适当的治疗。带状疱疹的表现可以在外观上有所不同,并不总是以标准的皮肤模式出现。当临床诊断含糊不清时,对明显的水疱性皮疹的模式识别与相关症状的高度怀疑,应提示通过DNA PCR培养水疱以诊断带状疱疹。早期发现将有助于加快适当的治疗和教育,以减少病毒的进一步传播。国际儿科临床杂志,2019;8(1):19-21 doi: https://doi.org/10.14740/ijcp334
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