Stem cells and lung injury

Abstract

The complex underlying mechanism for repair, proliferation, differentiation and remodeling after injury is a massive phenomenon in acute lung injury and their progression [1]. The recent progress in research shows the evidence that the stem cells may exhibit their trans-differentiation in organs including lung. The well established archetype of lung adult stem cells explored the knowledge about transient amplification of cell progeny [2]. Especially the lung is consisting of persistent tissue incorporated with infrequently proliferating epithelial, interstitial and endothelial cell populations [2]. There is a scarcity of classical stem cell hierarchy for these kinds of essential tissues [2]. It is known that some differentiated mature epithelial cells and denovo epithelial progenitors may also exhibit their role in repair mechanism [2]. The therapeutic target is the biggest problem to cure acute lung injury (ALI) at the molecular level, in this regards the researchers finding some important evidence to bring down the normal mechanism by treating with the stem cell therapeutics. This promising evidence may resemble their effective intervention against the progression of injury in the lung and promoting effect to develop as fibrosis. Our review explains about some important biomarkers role in lung injury and the effective stem cell therapies against the harmful biomarkers.