{"title":"Palmitoylethanolamide, adipocytes and obesity-related inflammatory states","authors":"Laurence Hoareau, Régis Roche","doi":"10.1016/j.ddmec.2011.01.002","DOIUrl":null,"url":null,"abstract":"<div><p>Obesity is characterized by ‘low grade’ and chronic inflammation<span><span>, which leads to pathologies such as insulin resistance, type 2 diabetes or </span>atherosclerosis. The role of the adipose tissue, and specifically adipocytes, in this process is discussed.</span></p><p>Besides, the palmitoylethanolamide (PEA), an endocannabinoid-like molecule, was revealed to have an overall anti-inflammatory effect; moreover, it is secreted by adipose tissue. Thus, this review aims to understand the role of PEA in adipocytes in the case of obesity-related inflammatory states.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 3","pages":"Pages e205-e212"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.01.002","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676511000034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Obesity is characterized by ‘low grade’ and chronic inflammation, which leads to pathologies such as insulin resistance, type 2 diabetes or atherosclerosis. The role of the adipose tissue, and specifically adipocytes, in this process is discussed.
Besides, the palmitoylethanolamide (PEA), an endocannabinoid-like molecule, was revealed to have an overall anti-inflammatory effect; moreover, it is secreted by adipose tissue. Thus, this review aims to understand the role of PEA in adipocytes in the case of obesity-related inflammatory states.
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