{"title":"Colonoscopy Audit Increases Detection of Sessile Serrated Polyps","authors":"A. Fraser","doi":"10.33696/pathology.2.030","DOIUrl":null,"url":null,"abstract":"Detection and removal of all adenomas at colonoscopy is associated with a reduced interval cancer rate [1,2]. This is consistent with the adenoma-carcinoma sequence for colorectal cancer. The identification of the serrated polyp cancer pathway has emphasized the importance of detection and removal of sessile serrated polyps. Serrated polyps are precursor lesions ac counting for 15% to 30% of colorectal cancers. They are overrepresented as a cause of interval cancers [3]. The detection of serrated polyps has been clearly linked to the risk of colorectal cancer in a prospective record linkage study in Sweden with a similar risk to tubular adenomas (HR of 1·77 (1·34-2·34) for sessile serrated polyps and 1·41 (1·30-1·52) for tubular adenomas) [4].","PeriodicalId":14157,"journal":{"name":"International Journal of Experimental Pathology","volume":"1 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Experimental Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.33696/pathology.2.030","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Detection and removal of all adenomas at colonoscopy is associated with a reduced interval cancer rate [1,2]. This is consistent with the adenoma-carcinoma sequence for colorectal cancer. The identification of the serrated polyp cancer pathway has emphasized the importance of detection and removal of sessile serrated polyps. Serrated polyps are precursor lesions ac counting for 15% to 30% of colorectal cancers. They are overrepresented as a cause of interval cancers [3]. The detection of serrated polyps has been clearly linked to the risk of colorectal cancer in a prospective record linkage study in Sweden with a similar risk to tubular adenomas (HR of 1·77 (1·34-2·34) for sessile serrated polyps and 1·41 (1·30-1·52) for tubular adenomas) [4].
期刊介绍:
Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes. The International Journal of Experimental Pathology - IJEP - publishes papers which afford new and imaginative insights into the basic mechanisms underlying human disease, including in vitro work, animal models, and clinical research.
Aiming to report on work that addresses the common theme of mechanism at a cellular and molecular level, IJEP publishes both original experimental investigations and review articles. Recent themes for review series have covered topics as diverse as "Viruses and Cancer", "Granulomatous Diseases", "Stem cells" and "Cardiovascular Pathology".