Anti-tumor activity of ethanolic extract of Crataeva magnaLour. (DC) against Dalton’s ascites lymphoma cell lines in mice

Abstract

http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(5).2757-2763 ABSTRACT:In recent years, the use of traditional medicine information in cancer research received considerable interest. Ethanolic Extract of Crataeva magnaLour. DC (EECM) has been used in traditional and folklore medicine for the treatment of cancer. The aim of the present investigation was to evaluate the effect of ethanolic extract root bark of Crataeva magnaLour. DC in swiss albino mice against intraperitoneally injected Dalton’s ascitic lymphoma (DAL) cell lines. DAL cells were injected intraperitoneally (1×10cells/ml/mouse) to the mice. The EECM at a dose of 200 mg/kg and 400mg/kg body weight were administered orally for 14 consecutive days to the tumor bearing group of animals. Derived parameters, hematological parameters, serum enzyme and lipid parameters were measured and compared to the control group. 5Flurouracil (20 mg/kg) was used as a standard drug. Both doses of EECM decreased average increase in body weight, reduced the packed cell volume (PCV) viable tumor cell count and increased the life span of DAL treated mice and brought back the hematological parameters, serum enzyme and lipid profile near to normal values. All the values were found to be statistically significant with control group at p<0.01. These observations are suggestive of the protective effect of extracts in Dalton’s Ascitic Lymphoma (DAL). All these findings enable to conclude that both doses of EECM possess a protective effect against DAL.