Conflict Trends of Autophagy on Cellular Senescence in Aged Tissues: A Systematic Review

Abstract

Background Recently, autophagy as a highly conserved catabolic intracellular process considered to be a promising therapeutic target particularly in pathological alternations under aging condition. This systematic review is designed to qualitatively analyzed the interaction between autophagy and aging in various organs of animal models. Methods: Based on our primary search, 9478 identified and following screening ultimately 80 full text were included to proceed further analysis. Next, by using SPSS software, data analysis of autophagy and aging related markers as well as autophagy alternation over the course of aging was performed. Results: Despite of debatable results, we established that the majority of studies showed that the autophagy process reduced in different aged organs significantly. Conclusion The outcomes showed that autophagy induction during aging were inferior to those reports that indicated the therapeutic potential of autophagy. Taken together, it should be considered that autophagy inducers could be counted as anti-aging agents.