CHITOSAN-COATED CALCIUM PHOSPHATE PARTICLES AS CARRIERS FOR DRUG DELIVERY TO OCULAR TISSUES

Abstract

Chitosan-covered calcium phosphate particles are promising carriers for the delivery of low-molecular-weight drugs to ocular tissues. The inclusion of the angiotensin-converting enzyme inhibitor enalaprilat into these particles increases the retention time of the drug in the tear, enhances the effectiveness of intraocular pressure decrease, and prolongs the drug action.