State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma.

IF 3.8 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2009-11-23 DOI:10.3892/OR_00000606

M. Yamatoji, A. Kasamatsu, Y. Yamano, K. Sakuma, K. Ogoshi, Manabu Iyoda, K. Shinozuka, K. Ogawara, Y. Takiguchi, M. Shiiba, H. Tanzawa, K. Uzawa

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引用次数: 30

Abstract

Homeobox (HOX) A10, the regulator of embryonic morphogenesis and differentiation, is aberrantly expressed in several cancer types. Our previous study using microarray technology showed that significant up-regulation of HOXA10 occurs in oral squamous cell carcinoma (OSCC)-derived cell lines compared to human normal oral keratinocytes (HNOKs). The aim of the current study was to examine the status of HOXA10 mRNA and protein expression in OSCC-derived cell lines and human primary OSCCs. HOXA10 mRNA was up-regulated in six OSCC-derived cell lines compared with HNOKs and in primary OSCCs by using real-time quantitative reverse transcriptase-polymerase chain reaction. Immunohistochemistry data indicated that HOXA10 protein expression levels were consistent with mRNA expression status in OSCC-derived cell lines and primary OSCCs. Furthermore, HOXA10 expression status was correlated with the TNM stage (P<0.05). These results indicate that HOXA10 expression could contribute to cancer progression and prognosis and that HOXA10 may be a potential diagnostic marker and a therapeutic target for OSCCs.

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同源盒A10表达状态作为口腔鳞状细胞癌的推测预后标志物。

同源盒(HOX) A10是胚胎形态发生和分化的调节因子，在几种癌症类型中异常表达。我们之前使用微阵列技术的研究表明，与人类正常口腔角质形成细胞(HNOKs)相比，口腔鳞状细胞癌(OSCC)衍生细胞系中HOXA10的显著上调。本研究的目的是检测HOXA10 mRNA和蛋白在oscc衍生细胞系和人原代oscc中的表达状况。通过实时定量逆转录-聚合酶链反应，与HNOKs相比，HOXA10 mRNA在6种oscc衍生细胞系中表达上调，在原代oscc中表达上调。免疫组化数据显示，HOXA10蛋白在oscc衍生细胞系和原代oscc中的表达水平与mRNA表达状态一致。HOXA10表达水平与TNM分期相关(P<0.05)。这些结果表明，HOXA10的表达可能有助于癌症的进展和预后，HOXA10可能是OSCCs的潜在诊断标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.