Adjuncts to pulsed dye laser for treatment of port wine stains: a literature review

IF 1.2 4区医学 Q3 DERMATOLOGY

Journal of Cosmetic and Laser Therapy Pub Date : 2021-11-17 DOI:10.1080/14764172.2022.2052901

Bin Wang, Xianglin Mei, Yanlong Wang, Xin Hu, Fuqiu Li

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引用次数: 2

Abstract

ABSTRACT Noninvasive pulsed dye laser is the current gold standard for the treatment of port wine stains. However, most port wine stains are not completely cleared after pulsed dye laser therapy, owing to insufficient photocoagulation and laser-induced vascular regeneration and reperfusion. Several studies have explored approaches designed to improve treatment efficacy. This integrative literature review summarizes the results of clinical and animal studies published between 2004 and 2021. Pulsed dye laser has been administered in combination with photoelectric devices (the neodymium: yttrium-aluminum-garnet lasers, dual-wavelength 1064-/595-nm laser irradiation, fiberoptic Nd-YAG laser, photodynamic therapy, and radio frequency), and drugs (rapamycin, imiquimod, timolol, axitinib, endothelin receptor antagonist, artificial red blood cells and oxymetazoline). The initial results suggest that combination therapy is a direction worth exploring in the future. Further large prospective, blinded and controlled multicenter clinical trials with longer follow‐up period are required to obtain more robust evidence.

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脉冲染料激光辅助治疗葡萄酒色斑的文献综述

无创脉冲染料激光是目前治疗葡萄酒色斑的金标准。然而，脉冲染料激光治疗后，由于光凝和激光诱导的血管再生和再灌注不足，大多数葡萄酒斑不能完全清除。一些研究已经探索了旨在提高治疗效果的方法。这篇综合文献综述总结了2004年至2021年间发表的临床和动物研究的结果。脉冲染料激光与光电器件(钕钇铝石榴石激光器、双波长1064-/595 nm激光照射、光纤Nd-YAG激光、光动力疗法和射频)和药物(雷帕霉素、咪喹莫特、替莫洛尔、阿西替尼、内皮素受体拮抗剂、人造红细胞和羟甲唑啉)联合使用。初步结果表明，联合治疗是未来值得探索的方向。需要进一步的大型前瞻性、盲法和对照多中心临床试验来获得更有力的证据。

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来源期刊

Journal of Cosmetic and Laser Therapy DERMATOLOGY-SURGERY

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： A unique journal that focuses on the application of cosmetic laser and light therapies on the skin. The Journal of Cosmetic & Laser Therapy provides a forum for stimulating and up-to-date studies demonstrating the wide range of therapeutic options for clinicians and surgeons involved in cosmetic and dermatological treatment. The journal is aimed at dermatologists, cosmetic surgeons, plastic and facial plastic surgeons, oculoplastic surgeons and all those interested in the rapidly expanding field of cosmetic and laser therapy. Features include: -Cosmetic surgery, including facial rejuvenation, hair removal and skin resurfacing -Use of lasers and other light sources for cosmetic and dermatological treatment -Applications of peeling agents, fillers, injectables, implants and other cosmetic modalities -Topical treatments -Practical tips and safety issues