{"title":"Neuere Antimycotika","authors":"Tibor Zsolnai","doi":"10.1016/S0172-5599(80)80047-2","DOIUrl":null,"url":null,"abstract":"<div><p>A number of N-aryl-dithiocarbamic-esters and their N-methyl-derivatives are produced and the fungistatic action of these compounds compared with one another.</p><p>It was demonstrated that N-aryl-dithiocarbamic-esters exert an intensive fungistatic action with a wide spectrum of activity, but their N-methyl-derivatives are in this respect totally inactive.</p><p>The N-aryl-dithiocarbamic-esters are transformed easily into arylisothiocyanates, but their N-methyl derivatives are unable to effect such transformation. These facts provide an indirect evidence of N-aryl-dithiocarbamic-esters to exert their fungistatic effect indeed by the formation of arylisothiocyanates <em>in situ</em>.</p><p>The fungistatic action of a number of aryl- and aralkyl-carbylaminchlorides, respectively, was examined. The fungistatic effect of the corresponding aryl- and aralkyl-isothiocyanates was examined in parallel to decide whether a difference between these two similar types of compounds in the intensity of their fungistatic effect exists.</p><p>It was demonstrated that the examined aryl- and aralkyl-carbylaminchlorides exert an intensive fungistatic effect, but their fungistatic activity is less intensive than that of the corresponding aryl- and aralkyl-isothiocyanates.</p><p>It was furthermore demonstrated that the fungistatic activity of aryl-isothiocyanates is considerably increased by a chlorine atom in the meta or para position or by a bromine atom in the para position of their molecules, but the fungistatic action of the aryl-carbylaminchlorides is significantly decreased by this on the contrary, the fungistatic activity of both series of compounds is increased by 3,4-dichloro substitution.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 410-417"},"PeriodicalIF":0.0000,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80047-2","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0172559980800472","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
A number of N-aryl-dithiocarbamic-esters and their N-methyl-derivatives are produced and the fungistatic action of these compounds compared with one another.
It was demonstrated that N-aryl-dithiocarbamic-esters exert an intensive fungistatic action with a wide spectrum of activity, but their N-methyl-derivatives are in this respect totally inactive.
The N-aryl-dithiocarbamic-esters are transformed easily into arylisothiocyanates, but their N-methyl derivatives are unable to effect such transformation. These facts provide an indirect evidence of N-aryl-dithiocarbamic-esters to exert their fungistatic effect indeed by the formation of arylisothiocyanates in situ.
The fungistatic action of a number of aryl- and aralkyl-carbylaminchlorides, respectively, was examined. The fungistatic effect of the corresponding aryl- and aralkyl-isothiocyanates was examined in parallel to decide whether a difference between these two similar types of compounds in the intensity of their fungistatic effect exists.
It was demonstrated that the examined aryl- and aralkyl-carbylaminchlorides exert an intensive fungistatic effect, but their fungistatic activity is less intensive than that of the corresponding aryl- and aralkyl-isothiocyanates.
It was furthermore demonstrated that the fungistatic activity of aryl-isothiocyanates is considerably increased by a chlorine atom in the meta or para position or by a bromine atom in the para position of their molecules, but the fungistatic action of the aryl-carbylaminchlorides is significantly decreased by this on the contrary, the fungistatic activity of both series of compounds is increased by 3,4-dichloro substitution.