The effect of squalene on lipid profile and some oxidative biomarkers in patients with type 2 diabetes mellitus

Functional Food Science Pub Date : 2022-07-21 DOI:10.31989/ffs.v2i7.949

H. Mirmiranpour, Mohammad Reza Ashoori, Afsaneh Seyed Mikaeili, S. Pezeshki, Anne Serani, Rachael Vassar, D. Martirosyan

{"title":"The effect of squalene on lipid profile and some oxidative biomarkers in patients with type 2 diabetes mellitus","authors":"H. Mirmiranpour, Mohammad Reza Ashoori, Afsaneh Seyed Mikaeili, S. Pezeshki, Anne Serani, Rachael Vassar, D. Martirosyan","doi":"10.31989/ffs.v2i7.949","DOIUrl":null,"url":null,"abstract":"Background: Squalene, as an isoprene, is one of the components of amaranth oil and makes up about 8% of this oil. Squalene has anti-inflammatory and antioxidant effects that have been considered in many studies. In people with uncontrolled diabetes, there is an increase in total cholesterol and low-density lipoprotein (LDL) alongside a decrease in high-density lipoproteins (HDL).According to studies, squalene can be useful in lowering total cholesterol and triacylglycerol.Objective: The aim of this study was to investigate whether squalene has an effect on lipid profile and a number of oxidative biomarkers in patients with type 2 diabetes.Methods: In the present study, 30 healthy volunteers were selected as the control group and 120 volunteers with type 2 diabetes mellitus (T2DM) were selected. Subjects with diabetes were randomly divided into 4 groups. Group 1 was untreated with squalene and groups 3, 4, and 5 were treated with different doses of squalene for 84 days. Lipid profiles and oxidant biomarkers were examined on days 1, 14, 28, 56, and 84 according to the relevant protocols in all groups.Results: Significant differences (P < 0.05) were observed between control and diabetic groups in the study of cholesterol, triglycerides, LDL, HDL, very low-density lipoproteins (VLDL), oxidized low-density lipoprotein (Ox-LDL), and malondialdehyde. There was a significant difference between the studied groups in the levels of parameters expressed in some different doses and days.At the levels of the parameters expressed in some doses and different days, a significant difference was observed between the groups treated and untreated with squalene.Conclusion: This study shows that squalene as a bioactive compound can be effective to manage certain symptoms of diabetics including HDL, LDL, total cholesterol, and VLDL. From our findings, we observed that squalene consumption over the duration of 84 days resulted in increased levels of HDL in diabetic patients. It also resulted in decreased levels of total cholesterol, LDL, and VLDL in diabetic patients. Keywords: Squalene, lipid profile, oxidative biomarkers, diabetes mellitus","PeriodicalId":12570,"journal":{"name":"Functional Food Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Functional Food Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31989/ffs.v2i7.949","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 7

Abstract

Background: Squalene, as an isoprene, is one of the components of amaranth oil and makes up about 8% of this oil. Squalene has anti-inflammatory and antioxidant effects that have been considered in many studies. In people with uncontrolled diabetes, there is an increase in total cholesterol and low-density lipoprotein (LDL) alongside a decrease in high-density lipoproteins (HDL).According to studies, squalene can be useful in lowering total cholesterol and triacylglycerol.Objective: The aim of this study was to investigate whether squalene has an effect on lipid profile and a number of oxidative biomarkers in patients with type 2 diabetes.Methods: In the present study, 30 healthy volunteers were selected as the control group and 120 volunteers with type 2 diabetes mellitus (T2DM) were selected. Subjects with diabetes were randomly divided into 4 groups. Group 1 was untreated with squalene and groups 3, 4, and 5 were treated with different doses of squalene for 84 days. Lipid profiles and oxidant biomarkers were examined on days 1, 14, 28, 56, and 84 according to the relevant protocols in all groups.Results: Significant differences (P < 0.05) were observed between control and diabetic groups in the study of cholesterol, triglycerides, LDL, HDL, very low-density lipoproteins (VLDL), oxidized low-density lipoprotein (Ox-LDL), and malondialdehyde. There was a significant difference between the studied groups in the levels of parameters expressed in some different doses and days.At the levels of the parameters expressed in some doses and different days, a significant difference was observed between the groups treated and untreated with squalene.Conclusion: This study shows that squalene as a bioactive compound can be effective to manage certain symptoms of diabetics including HDL, LDL, total cholesterol, and VLDL. From our findings, we observed that squalene consumption over the duration of 84 days resulted in increased levels of HDL in diabetic patients. It also resulted in decreased levels of total cholesterol, LDL, and VLDL in diabetic patients. Keywords: Squalene, lipid profile, oxidative biomarkers, diabetes mellitus

查看原文本刊更多论文

角鲨烯对2型糖尿病患者血脂及一些氧化生物标志物的影响

背景:角鲨烯是一种异戊二烯，是苋菜油的主要成分之一，约占苋菜油的8%。角鲨烯具有抗炎和抗氧化作用，已在许多研究中被考虑。在不受控制的糖尿病患者中，总胆固醇和低密度脂蛋白(LDL)增加，高密度脂蛋白(HDL)减少。根据研究，角鲨烯可用于降低总胆固醇和甘油三酯。目的:本研究的目的是研究角鲨烯是否对2型糖尿病患者的血脂和一些氧化生物标志物有影响。方法:选取30名健康志愿者作为对照组，120名2型糖尿病(T2DM)患者作为对照组。糖尿病患者随机分为4组。第1组不给予角鲨烯处理，第3、4、5组给予不同剂量角鲨烯处理，连续84 d。根据相关方案，在第1、14、28、56和84天检测各组的脂质谱和氧化生物标志物。结果:在胆固醇、甘油三酯、LDL、HDL、极低密度脂蛋白(VLDL)、氧化低密度脂蛋白(Ox-LDL)、丙二醛的研究中，对照组与糖尿病组有显著差异(P < 0.05)。在一些不同剂量和天数中，实验组之间表达的参数水平存在显著差异。在某些剂量和不同天数表达的参数水平上，角鲨烯处理组和未处理组之间存在显著差异。结论:本研究表明角鲨烯作为一种生物活性化合物可以有效地控制糖尿病的某些症状，包括HDL、LDL、总胆固醇和VLDL。根据我们的研究结果，我们观察到，在84天的时间内，角鲨烯的摄入导致糖尿病患者HDL水平升高。它还降低了糖尿病患者的总胆固醇、低密度脂蛋白和VLDL水平。关键词:角鲨烯，脂质谱，氧化生物标志物，糖尿病

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Functional Food Science

CiteScore

3.20

自引率

0.00%

发文量