Subcellular delivery of lipid nanoparticles to endoplasmic reticulum and mitochondria.

Yingying Shi, Zhenyu Luo, Jian You
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引用次数: 3

Abstract

Primarily responsible for the biogenesis and metabolism of biomolecules, endoplasmic reticulum (ER) and mitochondria are gradually becoming the targets of therapeutic modulation, whose physiological activities and pathological manifestations determine the functional capacity and even the survival of cells. Drug delivery systems with specific physicochemical properties (passive targeting), or modified by small molecular compounds, polypeptides, and biomembranes demonstrating tropism for ER and mitochondria (active targeting) are able to reduce the nonselective accumulation of drugs, enhancing efficacy while reducing side effects. Lipid nanoparticles feature high biocompatibility, diverse cargo loading, and flexible structure modification, which are frequently used for subcellular organelle-targeted delivery of therapeutics. However, there is still a lack of systematic understanding of lipid nanoparticle-based ER and mitochondria targeting. Herein, we review the pathological significance of drug selectively delivered to the ER and mitochondria. We also summarize the molecular basis and application prospects of lipid nanoparticle-based ER and mitochondria targeting strategies, which may provide guidance for the prevention and treatment of associated diseases and disorders. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Biology-Inspired Nanomaterials > Lipid-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.
脂质纳米颗粒向内质网和线粒体的亚细胞递送。
内质网(endoplasmic reticulum, ER)和线粒体主要负责生物分子的生物发生和代谢,它们逐渐成为治疗调节的靶点,其生理活动和病理表现决定着细胞的功能能力甚至存活。具有特定物理化学性质(被动靶向)或由小分子化合物、多肽和生物膜修饰的药物传递系统显示出内质网和线粒体的倾向(主动靶向),能够减少药物的非选择性积累,提高疗效,同时减少副作用。脂质纳米颗粒具有高生物相容性,多样化的货物负载和灵活的结构修饰,经常用于亚细胞细胞器靶向递送治疗。然而,目前对基于脂质纳米颗粒的内质网和线粒体靶向仍然缺乏系统的了解。在此,我们回顾了药物选择性递送到内质网和线粒体的病理意义。综述了基于脂质纳米颗粒的内质网和线粒体靶向策略的分子基础和应用前景,为相关疾病的预防和治疗提供指导。本文分类如下:治疗方法和药物发现>肿瘤疾病的纳米医学-生物学启发的纳米材料>基于脂质结构的生物学纳米技术方法>生物学诊断工具中的纳米系统>体内纳米诊断和成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
17.60
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