Determination of quaternary ammonium salts and polyhexamethylene biguanide hydrochloride in the coexistence in disinfectants and their biocidal activity

Yuliya Vladimirovna Matveichuk, Llc «Nordkhim», Dmitrii Vladislavovich Stanishevsky, Yu. V. Shabeka
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Abstract

Titrimetric methods for determining the concentration of quaternary ammonium salts and polyhexame­thylenebiguanide hydrochloride in the presence of a disinfectant are described. In addition, as auxiliary components, the agent contains a nonionic surfactant and an alkyl polyglucoside and a disodium salt of ethylenediaminetetraacetic acid as a complexing agent. The main differences between the methods proposed by us for the determination of quaternary ammonium salts and polyhexamethylenebiguanide hydrochloride is the use of not sodium dodecyl sulfate as a titrant, but a solution of the disinfectant itself, which greatly facilitated the visual fixation of the equivalence point. In addition, the volume of the indicator (methylene blue and bromophenol blue) was selected in such a way that the exposure between the portions of the added titrant was not prolonged, because this would increase the overall duration of the analysis. When titrating with polyhexamethylenebiguanide hydrochloride, the vo­lume of the indicator is selected in such a way as to minimize the interfering effect of HR, which are also part of disinfectants. The reproducibility of the developed methods has been confirmed in accredited laboratories of the relevant state institutions of the Republic of Belarus. Metrological characteristics of the developed methods: accuracy index±3.7 %, reproducibility index 4.0 %, n = 17, P = 0.95 – to determine the QAS; accuracy index±4.2 %, reproducibility index 5.5 %, n = 17, P = 0.95 – for the determination of PHMBG.
季铵盐与聚六亚甲基二胍在消毒剂中共存的测定及其杀菌活性
描述了在消毒剂存在下测定季铵盐和聚己二胍盐酸盐浓度的滴定法。此外,作为辅助组分,该剂含有非离子表面活性剂和烷基聚葡萄糖苷和乙二胺四乙酸二钠盐作为络合剂。我们所提出的测定季铵盐和聚六亚甲基二胍盐酸盐的方法的主要区别在于,不是使用十二烷基硫酸钠作为滴定剂,而是使用消毒剂本身的溶液,这大大方便了等当点的视觉固定。此外,指示剂(亚甲基蓝和溴酚蓝)的体积选择时,添加的滴定剂部分之间的暴露时间不会延长,因为这会增加分析的总体持续时间。用盐酸聚六亚二胍滴定时,指示剂的体积选择应尽量减少HR的干扰作用,HR也是消毒剂的一部分。所开发方法的可重复性已在白俄罗斯共和国有关国家机构的认可实验室中得到证实。所建立方法的计量特性:准确度指数为±3.7%,重现性指数为4.0%,n = 17, P = 0.95 -测定QAS;准确度为±4.2%,重现性为5.5%,n = 17, P = 0.95。
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