Effect of exposure to Benzene on oxidative stress and the functions of liver and kidney of male Albino Rat

Journal of Environmental and Occupational Science Pub Date : 2015-01-01 DOI:10.5455/JEOS.20141223050552

A. A. El-Shakour, Ahmad S. El-Ebiarie, Y. Ibrahim, A. Moneim, Asmaa El-Mekawy

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引用次数: 8

Abstract

Aim: Benzene is a volatile organic compound known to be carcinogenic to humans. The present study was conducted to determine the effects of exposure to average indoor concentrations of benzene on liver and kidney of rats. Methods: Adult male albino Wistar rats were exposed to 10, 30 and 50 ppm of benzene for 14 days. The effect on lipid peroxidation (LPO), nitric oxide (NO) and glutathione (GSH) as oxidative markers, in addition, liver and kidney function levels were determined in adult male rats. Results: Benzene intoxication increased the activities of liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and the bilirubin level, in addition to the levels of uric acid, urea and creatinine were increased in the serum. Moreover, benzene inhalation at 10, 30 and 50 ppm for 14 days in adult male rats enhanced LPO and NO production in both serum and liver with a concomitant reduction in GSH content. Conclusions: On the basis of the above results, it can hypothesis that benzene inhalation caused hepatic and renal damages even at low concentration.

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苯暴露对雄性白化大鼠氧化应激及肝肾功能的影响

目的:苯是一种挥发性有机化合物，已知对人类具有致癌性。本研究旨在确定室内苯平均浓度暴露对大鼠肝脏和肾脏的影响。方法:将成年雄性白化Wistar大鼠分别暴露于10、30、50 ppm的苯中14 d。以脂质过氧化(LPO)、一氧化氮(NO)和谷胱甘肽(GSH)为氧化标志物，测定其对成年雄性大鼠肝肾功能水平的影响。结果:苯中毒大鼠肝酶(丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶)活性升高，胆红素水平升高，血清尿酸、尿素、肌酐水平升高。此外，成年雄性大鼠在10、30和50 ppm浓度下吸入苯14天，血清和肝脏中LPO和NO的产生均增加，同时GSH含量降低。结论:基于以上结果，可以假设低浓度苯吸入也会引起肝、肾损害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Environmental and Occupational Science

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