The impact of vitamin D deficiency and microbiome in psoriasis versus non immune-mediated diseases

Abstract

Psoriasis consists of a chronic inflammatory disease with systemic character and may be associated with several comorbidities. Although its etiopathogenesis has not yet been fully elucidated, it is known that it is an immune-mediated pathology, especially by T cells. Like other inflammatory and autoimmune disorders, psoriasis is also related to changes in the cutaneous microbiome. Vitamin D deficiency is one of the conditions associated with pathologies whose microbiome is altered, although the causal relationship between these events is not precisely determined. Thus, the objective of this study was to estimate the prevalence of vitamin D deficiency in patients with psoriasis who attended the Dermatology Clinic of ABC Medical School (FMABC) and compare it to the prevalence of vitamin D deficiency among patients with non-inflammatory pathologies. 88 patients with psoriasis and 91 patients with non-inflammatory diseases (Control Group) were evaluated and had their serum vitamin D measured. It was observed that the Psoriasis Group had lower serum vitamin D levels compared to the Control Group (p<0.001) and It was observed that the chance of a person with psoriasis present low vitamin D levels is about seven times higher.