Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission.

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2023-04-01 DOI:10.2139/ssrn.4347409

Yimin Guo, Weimin Liu, Jie Sha, Xuewei Li, Haohui Ren, Jiasheng Wu, Wen-Jing Zhang, Chun-Sing Lee, Pengfei Wang

引用次数: 1

Abstract

The development of photosensitizers (PSs) with subcellular targeting capability has raised interest for photodynamic therapy (PDT) research. In this work, two coumarin-based photosensitizers (C-S-2 and C-S-3) were designed and synthesized via expanding their π-conjugation, introducing strong electron-donor and acceptor groups, and adopting sulfur substitution strategy. These sulfured-coumarins exhibited near-infrared emission (greater than 650 nm), lipid droplet-targeting ability and obvious photocytotoxicity under laser irradiation. In particular, C-S-3 exhibited better photostability, superior lipid droplet-targeting capability, and stronger photodynamic effect on cancer cells than C-S-2.

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基于近红外发射香豆素的脂滴靶向光敏剂的构建。

具有亚细胞靶向能力的光敏剂的开发引起了光动力治疗研究的兴趣。本文通过扩大π共轭，引入强电子给体和受体基团，采用硫取代策略，设计合成了两种香豆素类光敏剂C-S-2和C-S-3。这些含硫香豆素在激光照射下表现出近红外发射(大于650 nm)、脂滴靶向能力和明显的光细胞毒性。特别是C-S-3比C-S-2具有更好的光稳定性、更强的脂滴靶向能力和对癌细胞更强的光动力作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.