Abnormal High-sensitivity C-reactive Protein is Associated with an Increased Risk of Cardiovascular Disease and Renal Dysfunction among Patients Diagnosed with Type 2 Diabetes Mellitus in Palestine

Q3 Medicine

Review of Diabetic Studies Pub Date : 2022-03-09 DOI:10.1900/RDS.2022.18.27

M. Khattab, Moyad Shahwan, Nageeb Hassan, A. Jairoun

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引用次数: 1

Abstract

OBJECTIVE In this study, we aimed to evaluate the prevalence of high sensitivity C-reactive protein (hsCRP) as an inflammatory mediator and its association with renal function and other biochemical markers in patients with type 2 diabetes mellitus. METHODS We carried out a cross-sectional study at private healthcare center. We included 453 patients (48.6% males and 51.4% females) with type 2 diabetes mellitus. We obtained sociodemographic, clinical, and laboratory data from patient medical records. We carried out statistical analysis to ascertain associations between parameters. RESULTS The overall risk of cardiovascular disease (hsCRP > 1 mg/L) among the study participants was 27.2%. Age, gender, body mass index, fasting blood glucose and serum creatinine were significantly associated with risk of cardiovascular disease (hsCRP > 1 mg/L) whereas estimated glomerular filtration rate, vitamin B12, calcium, sodium and metformin users were negatively associated with the hsCRP. CONCLUSIONS We found a significant positive association of elevated level of C-reactive protein with type 2 diabetes mellitus. Moreover, additional to increased cardiovascular disease risk, hsCRP also seems to be a major inflammatory risk marker indicating renal function loss.

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在巴勒斯坦诊断为2型糖尿病的患者中，异常的高敏c反应蛋白与心血管疾病和肾功能障碍的风险增加有关

目的:在本研究中，我们旨在评估高敏感性c反应蛋白(hsCRP)作为炎症介质的患病率及其与2型糖尿病患者肾功能和其他生化指标的关系。方法在私立保健中心进行横断面研究。我们纳入453例2型糖尿病患者(男性48.6%，女性51.4%)。我们从患者的医疗记录中获得了社会人口学、临床和实验室数据。我们进行了统计分析以确定参数之间的联系。结果:研究参与者心血管疾病(hsCRP > 1 mg/L)的总风险为27.2%。年龄、性别、体重指数、空腹血糖和血清肌酐与心血管疾病风险显著相关(hsCRP > 1 mg/L)，而肾小球滤过率、维生素B12、钙、钠和二甲双胍使用者与hsCRP呈负相关。结论:我们发现c反应蛋白水平升高与2型糖尿病有显著正相关。此外，除了增加心血管疾病风险外，hsCRP似乎也是肾功能丧失的主要炎症风险标志物。

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来源期刊

Review of Diabetic Studies Medicine-Internal Medicine

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Review of Diabetic Studies (RDS) is the society"s peer-reviewed journal published quarterly. The purpose of The RDS is to support and encourage research in biomedical diabetes-related science including areas such as endocrinology, immunology, epidemiology, genetics, cell-based research, developmental research, bioengineering and disease management.