Micro Rna 182-3-P, 519-D-5p, 378-3p As Non-Invasive Predictors Of Preeclampsia.

IF 1.3 4区社会学 Q1 AREA STUDIES

Journal of Modern African Studies Pub Date : 2023-07-01 DOI:10.55519/JAMC-03-11783

Zaima Ali, Uzma Zafar, Ambreen Tauseef, Saima Zaki, Saba Khaliq

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引用次数: 0

Abstract

Background: MicroRNAs (miRNAs) are an emerging field of interest in many diseases. Some of the miRNAs have been reported to be expressed differentially in diseased states of pregnancy. The current study was designed to measure and compare the levels of microRNA 182-3-p, 519-d-5p, and 378-3p and it was hypothesized that the microRNA 182-3-p, 519-d-5p, and 378-3p can be used as a non-invasive predictor of preeclampsia.

Methods: Expression level of the miRNAs 182-3-p, 519-d-5p, and 378-3p was measured in the serum of preeclamptic and normal pregnancies by real-time PCR. Data was entered and analysed by Statistical Package for the Social Sciences 22 (SPSS).

Results: Significantly high expression levels of MiRNA 182-3p, 519-d-5p and low levels of miR-378-3p were associated with preeclampsia (PE).

Conclusions: The results revealed that miR-182-3p is a powerful predictor of PE with an Odds Ratio of 5.9 and can be used as a noninvasive, reliable predictor of PE to screen these patients at an early stage. Screening at early gestation with follow-up studies can emphasize the results.

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微 Rna 182-3-P、519-D-5p、378-3p 作为子痫前期的非侵入性预测因子。

背景：微小RNA（miRNA）是许多疾病的一个新兴研究领域。据报道，一些 miRNA 在妊娠疾病状态下的表达存在差异。本研究旨在测量和比较 microRNA 182-3-p、519-d-5p 和 378-3p 的水平，并假设 microRNA 182-3-p、519-d-5p 和 378-3p 可用作子痫前期的非侵入性预测指标：方法：通过实时 PCR 检测子痫前期和正常孕妇血清中 miRNA 182-3-p、519-d-5p 和 378-3p 的表达水平。数据由社会科学统计软件包 22（SPSS）输入和分析：结果：MiRNA 182-3p、519-d-5p的高表达水平和miR-378-3p的低表达水平与子痫前期（PE）明显相关：结果显示，miR-182-3p 是预测子痫前期的有力指标，Odds 比为 5.9，可作为子痫前期的非侵入性可靠预测指标，用于早期筛查这些患者。在妊娠早期进行筛查并进行随访研究能显著提高筛查效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Modern African Studies AREA STUDIES-

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Journal of Modern African Studies offers a quarterly survey of developments in modern African politics and society. Its main emphasis is on current issues in African politics, economies, societies and international relations. It is intended not only for students and academic specialists, but also for general readers and practitioners with a concern for modern Africa, living and working both inside and outside the continent. Editorial policy avoids commitment to any political viewpoint or ideology, but aims at a fair examination of controversial issues in order to promote a deeper understanding of what is happening in Africa today. The journal also includes an invaluable book review section.