Effectiveness of great burdock essence compounds in the adjuvant treatment of gastric ulcer patients infected with Helicobacter pylori

Abstract

Helicobacter pylori commonly infects the human stomach lining is one of the risk factors that can lead a gastric ulcer to develop into gastric cancer. Studies have found that burdock can enhance the protection of gastrointestinal mucosa with antibacterial property that can reduce the damage of the stomach by H pylori. Great burdock essence compounds are prepared using a nanomicell formulation, which contains Arctium lappa Linn, Arnebia euchroma, and Angelica sinensis. This study aims to assess the effectiveness of great burdock essence compounds in the adjuvant treatment of H pylori infected clinical patients. Forty-four patients with gastric ulcers, 21 of whom were taking great burdock essence compounds and 23 taking placebo, were included in this study. After taking great burdock essence compounds or placebo for 1 month, ¹³C-Urea Breath Test showed 20 (20/21) patients with negative results and only one person with positive results among the burdock group; in addition, it also indicated that there were 1 6(16/23) with negative results and seven (7/23) patients with positive results among the placebo group. The statistical results also showed that the positive ¹³C-Urea Breath Test results in patients who took great burdock essence compounds were significantly lower than that of the control group (p = 0.027). It suggested that great burdock essence is an appropriate health supplement for gastric ulcer patients with H pylori infection.