Histological Assessment of an Experimental Model of Human Osteomyelitis in Rabbits

“Agriculture for Life, Life for Agriculture” Conference Proceedings Pub Date : 2018-07-01 DOI:10.2478/alife-2018-0065

C. Coman, C. Surdu-Bob, F. Bărbuceanu, E. Vlase, M. Badulescu

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引用次数: 1

Abstract

Abstract The aim of this paper was to present a histological evaluation of the treatment performed on a humanmodel of osteomyelitis induced in rabbits. Osteomyelitis was induced in rabbits by a human strain of Staphylococcus aureus injected in bone defects created in the rabbit tibia. There have been created five groups of animals, groups receiving treatment in two different stages of the disease, acute and chronic. Copper and silver sub-millimetre-particles were introduced in the same place with the Staphylococcus solution. Evaluation of installation and evolution of the disease was done by clinical, hematological, microbiological, radiological and histological monitoring. A separate study of histological data is presented here. Histological examinations performed by HE was done on 5 μm sections of uncalcified bone. Every examination was classified according to a system of score. The results of histopathological evaluation confirm that histological analysis is a powerful tool in experimental models of this disease.

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兔人骨髓炎实验模型的组织学评价

摘要:本文的目的是提出一个组织学评价的治疗进行了人源性骨髓炎兔模型。将一种人类金黄色葡萄球菌菌株注射到兔胫骨骨缺损中诱导兔骨髓炎。已经创建了五组动物，每组在疾病的两个不同阶段接受治疗，急性和慢性。将亚毫米级的铜和银颗粒与葡萄球菌溶液放在同一位置。通过临床、血液学、微生物学、放射学和组织学监测来评估疾病的发生和发展。这里提出了一项单独的组织学数据研究。对未钙化骨5 μm切片进行HE组织学检查。每次考试都按分数制度进行分类。组织病理学评估结果证实，组织病理学分析是该疾病实验模型的有力工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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“Agriculture for Life, Life for Agriculture” Conference Proceedings

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