Diagnostic use of the resistive device in COPD patients

O. V. Grishin, V. Gultyaeva, D. Uryumtsev, M. Zinchenko, V. Grishin
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Abstract

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is diagnosed in later or very advanced stages. The aim of the study was to evaluate feasibility of low respiratory resistive load (LRRL) in patients with COPD for a new objective method of early COPD diagnostics and to examine changes in pulmonary gas exchange during LRRL. METHODS: The study involved eleven patients with mild or moderate COPD and fourteen healthy adult volunteers. After anthropometric and spirometric measuring, pulmonary gas exchange was measured for 7 minutes using the breath-by-breath method under two conditions: 1) without respiratory resistive load (WRL); 2) with LRRL 0.4 cm H2O · l-1 · s. Valve system (Intersurgical, UK) was used as a resistive device. RESULTS: Decrease in oxygen consumption (VO2) and carbon dioxide production (VCO2) during LRRL was significantly greater in COPD patients than in healthy subjects (14 vs. 8 %, p<;0.009 and 16 vs. 10 %, p<;0.020 respectively). In contrast, tidal volume increased by 13 % in healthy subjects only. CONCLUSION: Pulmonary gas exchange shift during low respiratory resistive load appears to be a feasible criterion of early COPD diagnostics. Future research is needed to examine sensitivity and specificity of the method.
阻性装置在慢性阻塞性肺病患者中的诊断应用
慢性阻塞性肺疾病(COPD)在晚期或非常晚期被诊断出来。本研究的目的是评估低呼吸阻力负荷(LRRL)在COPD患者中作为一种新的、客观的COPD早期诊断方法的可行性,并研究LRRL期间肺气体交换的变化。方法:该研究纳入了11名轻中度COPD患者和14名健康成人志愿者。在人体测量和肺活量测量后,在两种情况下,采用呼吸法测量肺气体交换7分钟:1)无呼吸阻力负荷(WRL);2) LRRL为0.4 cm H2O·l-1·s。采用英国Intersurgical公司的瓣膜系统作为电阻装置。结果:COPD患者在LRRL期间的耗氧量(VO2)和二氧化碳产生(VCO2)的下降明显大于健康受试者(分别为14%比8%,p< 0.009和16%比10%,p< 0.020)。相比之下,只有健康受试者的潮气量增加了13%。结论:低呼吸阻力负荷时肺气体交换移位是COPD早期诊断的可行标准。需要进一步的研究来检验该方法的敏感性和特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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