Combretum hypopilinum exhibited anti-inflammatory activity in LPS-stimulated RAW 264.7 murine macrophages through inhibition of inflammatory mediators and apoptosis

Q2 Pharmacology, Toxicology and Pharmaceutics

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI:10.7324/japs.2023.119177

K. Idoh, K. Dosseh, Mrinmoy Gautam, Tchazou Kpatcha, N. Manikandan, A. Agbonon, M. Ramanathan, M. Gbéassor

引用次数: 0

Abstract

This study has investigated the effects of Combretum hypopilinum on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells. Dried root bark of C. hypopilinum was extracted with dichloromethane, ethyl acetate, and ethanol to give three extracts. To select the most protective extract, RAW 264.7 cells were treated with each extract (10, 20, 40

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Combretum hypoopilinum通过抑制炎症介质和细胞凋亡，对lps刺激的小鼠巨噬细胞表现出抗炎活性

本研究探讨了低棘豆对脂多糖(LPS)诱导的RAW 264.7细胞炎症的影响。以二氯甲烷、乙酸乙酯和乙醇为萃取剂，得到三种提取物。为了选择最具保护作用的提取物，分别用10、20、40种提取物处理RAW 264.7细胞

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

journal of applied pharmaceutical science Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

2.20

自引率

0.00%

发文量

224

期刊介绍： Journal of Applied Pharmaceutical Science (JAPS) is a monthly, international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. JAPS publishes manuscripts (Original research and review articles Mini-reviews, Short communication) on original work, either experimental or theoretical in the following areas; Pharmaceutics & Biopharmaceutics Novel & Targeted Drug Delivery Nanotechnology & Nanomedicine Pharmaceutical Chemistry Pharmacognosy & Ethnobotany Phytochemistry Pharmacology & Toxicology Pharmaceutical Biotechnology & Microbiology Pharmacy practice & Hospital Pharmacy Pharmacogenomics Pharmacovigilance Natural Product Research Drug Regulatory Affairs Case Study & Full clinical trials Biomaterials & Bioactive polymers Analytical Chemistry Physical Pharmacy.