Development and Validation of HPTLC SIAM for Furosemide and Spironolactone

S. Vanjari, T. Deshmukh
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Abstract

ABSTRACT: "Diuretics," like spirolactone and furosemide, help the kidneys eliminate excess water. It also reduces fluid-induced hypertension and maintains blood potassium levels. Both Furosemide (FRU) and Spironolactone (SPL) can be measured at the same time with the help of HPTLC chromatographic method that have been shown to be very selective and accurate. There are a number of causes of edema, and FRU can help with all of them, including hepatic cirrhosis, chronic congestive heart failure, and excessive blood pressure. Heart failure and ascites caused by hepatic diseases are commonly treated with spironolactone due to its properties as an aldosterone antagonist and potassium-sparing diuretic. HPTLC methods were developed in this research to determine FRU and SPL simultaneously without using the solvents generally needed in chromatographic procedures. The proposed HPTLC approach stood out as an analytical method for quality control laboratories due to its speed, low cost, and ability to concurrently determine the target chemicals with a small number of solvents. The selectivity, accuracy, and reproducibility of the procedures for the simultaneous determination of the pure and mixed drug forms studied were further confirmed by statistical analysis.
呋塞米和螺内酯hplc - SIAM的建立与验证
摘要:“利尿剂”,如螺内酯和速尿,可以帮助肾脏排出多余的水分。它还能降低液体性高血压,维持血钾水平。高效液相色谱法可同时测定速尿(FRU)和螺内酯(SPL),具有很高的选择性和准确性。引起水肿的原因有很多,FRU可以帮助解决所有这些问题,包括肝硬化、慢性充血性心力衰竭和血压过高。由于螺内酯作为醛固酮拮抗剂和保钾利尿剂的特性,肝脏疾病引起的心力衰竭和腹水通常用螺内酯治疗。本研究开发了HPTLC方法,可以同时测定FRU和SPL,而无需使用色谱过程中通常需要的溶剂。所提出的HPTLC方法因其速度快、成本低、能够使用少量溶剂同时确定目标化学物质而成为质量控制实验室的一种分析方法。统计分析进一步证实了该方法的选择性、准确性和重现性,该方法可同时测定所研究的纯制剂和混合制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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