A new approach towards an optimum design and manufacture of microfluidic devices based on ex situ fabricated hydrogel based thin films' integration

2012 IEEE 62nd Electronic Components and Technology Conference Pub Date : 2012-07-30 DOI:10.1109/ECTC.2012.6249114

Weiwei Zhao, T. Santaniello, P. Webb, C. Lenardi, Changqing Liu

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引用次数: 1

Abstract

We present a compression based packaging technique which can be applied to reversibly seal hydrogel based materials' thin films and micro-fabricated thermoplastic components for hybrid materials stacking microfluidic cells-based chips design. A multilayer microdevice has been realized for liquid leakage tests at the thermoplastic/hydrogel interface nearby the fluidic circuits machined on the plastic layer; biocompatible Poly-hydroxyethylmethacrylate (PHEMA) hydrogel membranes with different thickness (Ranging from 100 to 200 μm) and micro-milled Polymethylmethacrylate components were chosen to realize the chip. By promoting continuous perfusion of the system pumping aqueous coloured dye solutions in the microchannels, the sealing between the two materials resulted guaranteed for tested flow rate values, ranging from 100nL/min to 10mL/min. Furthermore, to take the hydrogel into operation, a representative case study of a micro-bioreactor based on joint hybrid materials and employing PHEMA thin film as a cell culture substrate has been analyzed and modelled by mean of numerical simulation.

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基于非原位制备水凝胶薄膜集成的微流控器件优化设计与制造新途径

我们提出了一种基于压缩的封装技术，该技术可用于可逆密封水凝胶基材料薄膜和微加工热塑性元件，用于混合材料堆叠微流控电池芯片设计。在塑料层上加工的流体电路附近的热塑性/水凝胶界面处，实现了一种用于液体泄漏测试的多层微装置;选择不同厚度(100 ~ 200 μm)的生物相容性聚甲基丙烯酸羟乙酯(PHEMA)水凝胶膜和微磨聚甲基丙烯酸甲酯组分来实现芯片。通过促进系统在微通道中泵送有色染料水溶液的连续灌注，两种材料之间的密封保证了测试流速值，范围从100nL/min到10mL/min。此外，为了使水凝胶投入使用，对以PHEMA薄膜为细胞培养底物的联合杂化材料微生物反应器的代表性案例进行了分析和数值模拟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2012 IEEE 62nd Electronic Components and Technology Conference

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