Natural film based on collagen and sulfated polysaccharide for antiplatelet effects

IF 1.7 4区工程技术 Q4 POLYMER SCIENCE

International Journal of Polymer Analysis and Characterization Pub Date : 2022-10-01 DOI:10.1080/1023666X.2022.2103240

Ana Angélica Mathias Macêdo , Sônia Duarte Figueiró , Júlio César Góes Ferreira , Márcia Rúbia Silva Melo , Ana Lúcia Ponte Freitas , Antônio Sérgio Bezerra Sombra , Beatriz da Silva Batista , Romicy rmondes De Souza , Rafael Mendonça Almeida , Fernando Mendes , Renato de Azevedo Moreira

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引用次数: 0

Abstract

Although several properties of collagen have been explored, the blend formation with sulfated polymers is poorly explored. Antiplatelet effects can be achieved after the formation of this type of blend. In this work, a film formed by collagen and sulfated polysaccharide and their properties were analyzed. Five blends were produced, blend with collagen (10 mg/g) and 0, 5, 10, 20, and 25% of the sulfated polysaccharide. No changes amine (I, II, and III) vibrations alterations were observed, where the collagen structure remained unchanged. In addition, it was also observed the presence of sulfoxide groups related to the presence of sulfated polysaccharides. The samples have the same thermal degradation profile. Additionally, the stability of the film is up to 100 °C, characterized by the loss of water from the structure caused by the break-up of the blend. Also, it was verified that the adhesion of platelets to the collagen decreases with the presence of sulfated polysaccharide. The synthesized material presents a potential for application as an anti-thrombogenic agent, besides being biodegradable and biocompatible.

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基于胶原蛋白和硫酸多糖的天然膜抗血小板作用

虽然胶原蛋白的一些特性已经被探索，但与硫酸盐聚合物的共混形成的探索很少。这种共混物形成后可达到抗血小板作用。本文对胶原蛋白与硫酸酸化多糖形成的薄膜及其性质进行了分析。生产了五种混合物，分别与胶原蛋白(10 mg/g)和0,5,10,20和25%的硫酸酸化多糖混合。没有改变胺(I, II和III)振动的变化，其中胶原蛋白结构保持不变。此外，还观察到亚砜基团的存在与硫酸化多糖的存在有关。样品具有相同的热降解谱。此外，薄膜的稳定性高达100°C，其特点是由于共混物的破裂导致结构中的水分损失。此外，还证实了血小板与胶原蛋白的粘附性随着硫酸化多糖的存在而降低。该合成材料除了具有可生物降解和生物相容性外，还具有作为抗血栓形成剂的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Polymer Analysis and Characterization 化学-高分子科学

CiteScore

3.50

自引率

5.30%

发文量

审稿时长

1.6 months

期刊介绍： The scope of the journal is to publish original contributions and reviews on studies, methodologies, instrumentation, and applications involving the analysis and characterization of polymers and polymeric-based materials, including synthetic polymers, blends, composites, fibers, coatings, supramolecular structures, polysaccharides, and biopolymers. The Journal will accept papers and review articles on the following topics and research areas involving fundamental and applied studies of polymer analysis and characterization: Characterization and analysis of new and existing polymers and polymeric-based materials. Design and evaluation of analytical instrumentation and physical testing equipment. Determination of molecular weight, size, conformation, branching, cross-linking, chemical structure, and sequence distribution. Using separation, spectroscopic, and scattering techniques. Surface characterization of polymeric materials. Measurement of solution and bulk properties and behavior of polymers. Studies involving structure-property-processing relationships, and polymer aging. Analysis of oligomeric materials. Analysis of polymer additives and decomposition products.