Synthesis of Quinolinequinone Derivatives and related Carbocyclic Compounds

Uchechukwu, T. Wirth, S. A. Egu
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引用次数: 2

Abstract

Palladium-catalyzed Buchwald-Hartwig aminations of various quinolinequinone derivatives give excellent yields of novel 6-arylamino derivatives of the disubstituted quinolinequinones and 3-arylamino derivatives of the corresponding naphthoquinones. The precursor quinolinequinones are prepared in a three-step sequence from 8-hydroxyquinoline. The transition-metal catalyzed arylations of 6,7-dibromo-5,8-quinolinequinone, 6,7-chloro-5,8-quinolinequinone and 2,3-dichloro-1,4-naphthoquinone are reported for the first time and offer fast and easy access to their derivatives.
喹啉醌衍生物及相关碳环化合物的合成
钯催化的各种喹啉醌衍生物的Buchwald-Hartwig胺化反应得到了新的二取代喹啉醌的6-芳基衍生物和相应的萘醌的3-芳基衍生物的优异产率。前体喹啉醌由8-羟基喹啉按三步制得。本文首次报道了6,7-二溴-5,8-喹啉醌、6,7-氯-5,8-喹啉醌和2,3-二氯-1,4-萘醌在过渡金属催化下的芳基化反应,为其衍生物的制备提供了方便快捷的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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