Adverse Events Encountered in Platelet Aphaeresis Procedure and Their Management: A Retrospective Study

P. Gupta, D. Sharma, U. Yadav, J. Bindal
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Abstract

Background: Platelet aphaeresis is an essential procedure, which meets the demand of single donor platelets (SDP) effectively. The procedure is well tolerated by donors with fewer side effects. Adverse events in Platelet aphaeresis have been reported from as low as 0.32 to 6.81%. Aims and Objectives:  The aim of present study is to ascertain adverse events observed in a large cohort of platelet aphaeresis procedures and determining management strategies to resolve them. Materials and Methods: This is a retrospective cross-sectional study, from January 2012 to May 2019 in Blood Bank, Department of Pathology, in a tertiary care centre in Central India. Donors for Platelet aphaeresis were selected based on the standard criteria of National Aids Control Organization (NACO) guidelines 2017 and Platelet aphaeresis protocol. Leukoreduced SDP were collected by Haemonetics® MCS +, having Leukoreduction bag system. Adverse events encountered were noted and categorized. Results: A total number of 1600 Plateletpheresis procedures were conducted to prepare SDP and transfused to 1054 patients. A total of 24 out of 1600 plateletaphaeresis procedures reported adverse events (1.5%). Donor related adverse events were 16 (66.6%), Kit related 4 (16.66%) procedure related were 4 (16.66%). Three out of 24 procedures were terminated prematurely, 1 due to severe hypocalcaemia (ACD effect) in donor and 2 due to bowl leakage. Conclusion: Platelet aphaeresis is a safe procedure for donors if done expertly while exercising caution. Adverse events reported are minimal and manageable.
血小板分离过程中遇到的不良事件及其处理:一项回顾性研究
背景:血小板分离是有效满足单供血小板需求的必要步骤。供体对该手术的耐受性良好,副作用少。据报道,血小板分离的不良事件低至0.32%至6.81%。目的和目的:本研究的目的是确定在大队列血小板分离过程中观察到的不良事件,并确定解决这些不良事件的管理策略。材料和方法:这是一项回顾性横断面研究,于2012年1月至2019年5月在印度中部一家三级保健中心病理学部血库进行。根据国家艾滋病控制组织(NACO) 2017年指南和血小板分离方案的标准标准选择血小板分离献血者。白细胞诱导的SDP由Haemonetics®MCS +收集,具有白细胞诱导袋系统。记录和分类遇到的不良事件。结果:共进行血小板提取1600次,制备SDP,输注1054例。1600例血小板摘除术中有24例报告了不良事件(1.5%)。供体相关不良事件16例(66.6%),试剂盒相关不良事件4例(16.66%),手术相关不良事件4例(16.66%)。24例手术中有3例提前终止,1例是由于供体严重低钙(ACD效应),2例是由于盆腔渗漏。结论:对于献血者,如果操作熟练,同时谨慎操作,血小板分离是一种安全的操作。报告的不良事件是最小的和可控的。
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