Seladoeneolignan A, a new neolignan from Selaginella doederleinii Hieron.

Journal of Holistic Integrative Pharmacy Pub Date : 2022-09-01 DOI:10.1016/S2707-3688(23)00042-0

Minyu CHEN , Ni ZHENG , Wenqi LIU , Dingrong WAN , Rumei LU , Xinzhou YANG

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Abstract

Objective

To study the chemical compositions from Selaginella doederleinii Hieron.

Methods

The petroleum ether and ethyl acetate fractions of 80% ethanol extract of S. doederleinii were separated and purified by macroporous resin, silica gel, Sephadex LH-20 and semi-preparative HPLC, and then the structures of obtained compounds were identified by physicochemical properties and spectroscopical data.

Results

A total of 7 compounds were isolated and identified as seladoeneolignan A (1), ethoxy-ferulate (2), 11-dien-19-oic acid (3), aurantiamide (4), 9,16-dioxo-10,12,14-octadeca-trienoic acid (5), amentoflavone (6), and 7,4’-di-0-methylrobustaflavone (7).

Conclusion

Compound 1 was a new neolignan obtaind from S. doederleinii for the first time. Compounds 1, 6 and 7 were screened for antitumor activity in vitro, and the testing results showed that 3 compounds had low inhibitory activity on Hep-2 and Eca-109 tumor cells.

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Seladoeneolignan A，一种新木聚糖属植物。

目的研究卷柏的化学成分。方法采用大孔树脂、硅胶、Sephadex LH-20和半制备高效液相色谱法对菟丝子80%乙醇提取物的石油醚和乙酸乙酯组分进行分离纯化，通过理化性质和波谱数据对化合物结构进行鉴定。结果共分离得到7个化合物，鉴定为seladoeneolstanan A(1)、乙氧基阿魏酸(2)、11-二烯-19-酸(3)、金酰胺(4)、9,16-二氧基-10,12,14-十八烯-三烯酸(5)、amentoflavone(6)和7,4′-二-0-甲基robustadflavone(7)。结论化合物1为首次从菟丝子中分离得到的新木脂素。对化合物1、6、7进行体外抗肿瘤活性筛选，结果表明3个化合物对Hep-2和Eca-109肿瘤细胞具有较低的抑制活性。

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Journal of Holistic Integrative Pharmacy

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