Protective role of turmeric against deltamethrin induced renal oxidative damage in rats

Shiddappa Mallappa Shivanoor, Muniswamy David
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引用次数: 12

Abstract

The objective of this study was to investigate the antioxidant potential of turmeric (TMR) (1% turmeric-diet) against the renal toxicity induced by deltamethrin (DLM) (41 ppm) in rats. Male Wistar rats were randomly divided into four groups of sex each: a control group and three treated groups during 7 weeks with TMR alone and DLM administrated either alone in drinking water for DLM group or co-administred with TMR for DLM + TMR group. Results showed that DLM caused a significant reduction in body weight and kidney absolute and relative weight and decreased antioxidant enzyme activity accompanied by significant (P < 0.001) increased renal MDA, serum urea and creatinine levels compared to control. Histopathologically, DLM caused dilatation of proximal tubules, tubular cell desquamation, inflammatory cell infiltration, degeneration and necrosis. TMR co-administration significantly restored oxidative enzymes activity, serum biochemistry, MDA level and histological alterations caused by DLM. However, all these changes were monitored by Fourier transform–infrared spectroscopy (FT–IR) technique, reflecting the alteration in the biomolecules due to the oxidative stress caused by DLM intoxication. While, TMR co-administration brought them near to the control, it can be concluded that TMR has beneficial influences and could be able to antagonize DLM caused oxidative stress, changes in serum biochemistry and histopathological alterations in male Wister rats.

姜黄对溴氰菊酯所致大鼠肾脏氧化损伤的保护作用
本研究旨在探讨1%姜黄饲料(TMR)对41 ppm溴氰菊酯(DLM)致大鼠肾毒性的抗氧化作用。雄性Wistar大鼠随机分为4组,每组性别:对照组和3个治疗组,在7周内分别单独给予TMR和DLM, DLM组单独给予饮用水,DLM + TMR组与TMR共同给予。结果表明,DLM可显著降低大鼠体重、肾脏绝对和相对重量,降低抗氧化酶活性,并伴有显著的(P <0.001),与对照组相比,肾丙二醛、血清尿素和肌酐水平升高。组织病理学上,DLM引起近端小管扩张、小管细胞脱屑、炎症细胞浸润、变性和坏死。TMR联合给药可显著恢复DLM引起的氧化酶活性、血清生化、MDA水平和组织学改变。然而,傅立叶变换红外光谱(FT-IR)技术监测了所有这些变化,反映了DLM中毒引起的氧化应激引起的生物分子的变化。然而,TMR联合给药使它们接近对照组,可以得出结论,TMR具有有益的影响,可以拮抗DLM引起的雄性Wister大鼠的氧化应激、血清生化变化和组织病理学改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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