TiO₂ nanotube platforms for smart drug delivery: a review.

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2016-09-21 eCollection Date: 2016-01-01 DOI:10.2147/IJN.S108847

Qun Wang, Jian-Ying Huang, Hua-Qiong Li, Zhong Chen, Allan Zi-Jian Zhao, Yi Wang, Ke-Qin Zhang, Hong-Tao Sun, Salem S Al-Deyab, Yue-Kun Lai

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引用次数: 0

Abstract

Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided.

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用于智能给药的 TiO2 纳米管平台：综述。

钛纳米管（TNT）阵列因其优异的性能和简便的制备工艺，被公认为是一种很有前景的局部给药植入材料。考虑到 TNT 在一系列体内外研究中表现出的出色生物相容性，本综述重点介绍了基于 TNT 的局部给药系统的概念。考虑到TNT植入物在宿主体内的安全性，生物相容性研究对TNT植入物的临床应用具有重要意义。针对可持续给药的智能 TNT 平台，本综述介绍了几种先进的方法，包括由温度、光、射频磁和超声波刺激触发的控释。此外，牙科、骨科植入物、心血管支架等各种实例也证明了 TNT 植入物在医疗中的应用。最后，还展望了TNT在临床应用中的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.