Recent developments in encapsulation of α-lipoic acid for enhanced bioavailability and stability

P. Choudhary, S. Dutta, J. Moses, C. Anandharamakrishnan
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引用次数: 4

Abstract

α-lipoic acid (LA) is a potent antioxidant available in various plant and animal sources. Of late, there is high market demand for LA-based nutraceuticals, owing to enhanced occurrences of oxidative stress-based diseases. However, the effectiveness of LA is challenged with its low solubility, less stability, and low bioavailability. In addition, the unpleasant taste of LA limits its applications in food systems. In this context, encapsulation techniques can modify the chemical and biological properties of LA and improve its solubility and stability in the aqueous medium, which in turn helps in the development of different innovative therapeutic products based on LA. Different encapsulation techniques such as inclusion complexes, spray drying, electrospraying, solid lipid nanoparticles (SLN), emulsification, and liposomes have been explored for the encapsulation of LA. This review focuses on the biological activities of LA in terms of antioxidant, antidiabetic, anticancer, and anti-inflammatory properties, and the scope of encapsulation to enhance these properties, as evidenced through in vitro and in vivo studies. Furthermore, this article will help researchers and industrialists to select the suitable encapsulation method based on their requirement for delivering LA to achieve its optimal therapeutic potential.
α-硫辛酸包封提高生物利用度和稳定性的研究进展
α-硫辛酸(LA)是一种有效的抗氧化剂,存在于多种植物和动物中。最近,由于氧化应激疾病的发生率增加,对以洛杉矶为基础的营养保健品的市场需求很高。然而,LA的有效性受到其溶解度低、稳定性差和生物利用度低等问题的挑战。此外,LA令人不快的味道限制了它在食品系统中的应用。在这种情况下,包封技术可以改变LA的化学和生物学特性,提高其在水介质中的溶解度和稳定性,从而有助于开发基于LA的各种创新治疗产品。不同的包封技术,如包合物、喷雾干燥、电喷雾、固体脂质纳米颗粒(SLN)、乳化和脂质体,已经被探索用于LA的包封。本文综述了LA在抗氧化、抗糖尿病、抗癌和抗炎方面的生物活性,以及通过体外和体内研究证明的胶囊化增强这些特性的范围。此外,本文将帮助研究人员和实业家根据其递送LA的需求选择合适的封装方法,以实现其最佳治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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