The Burden of Respiratory Alterations during Sleep on Comorbidities in Obstructive Sleep Apnoea (OSA).

IF 0.5 4区数学 Q3 MATHEMATICS

Glasgow Mathematical Journal Pub Date : 2022-10-06 DOI:10.3390/brainsci12101359

Pasquale Tondo, Francesco Fanfulla, Giulia Scioscia, Roberto Sabato, Michela Salvemini, Cosimo C De Pace, Maria Pia Foschino Barbaro, Donato Lacedonia

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引用次数: 0

Abstract

Background: Obstructive sleep apnoea (OSA) has an important impact on the risk of morbidity and mortality, so we have designed the present study to understand which factor is most involved in the risk of developing a comorbidity between OSA severity and nocturnal hypoxemia.

Methods: A retrospective study was conducted on 617 adult subjects who were referred to our unit for a suspicion of OSA between January 2018 and January 2020.

Results: Sleep investigations performed by participants (72% male and obese in 70% of cases) reported an overall mean apnoea-hypopnoea index (AHI) of 44.0 ± 24.8 events·h^-1. Overall, 66% were classified as severe OSA and 76% experienced nocturnal hypoxemia. By analysing the burden of OSA severity and nocturnal hypoxemia on the comorbidities risk, multivariate analysis highlighted the predominant role of age and obesity. Accordingly, after the exclusion of the older and obese participants from the analyses, we noticed that severe OSA was related to the risk of hypertension (odds ratio (OR) = 3.0 [95% confidence interval [CI] 1.4-6.2], p = 0.004) as well as nocturnal hypoxemia (OR = 2.6 [95% CI 1.2-5.4], p = 0.01).

Conclusions: The study seems to suggest that in young, non-obese subjects, OSA is a predisposing factor for the risk of developing hypertension.

查看原文本刊更多论文

阻塞性睡眠呼吸暂停 (OSA) 患者睡眠时呼吸改变对并发症的影响。

背景：阻塞性睡眠呼吸暂停（OSA）对发病和死亡风险有重要影响，因此我们设计了本研究，以了解OSA严重程度和夜间低氧血症之间的合并症风险与哪个因素关系最大：我们对2018年1月至2020年1月期间因怀疑患有OSA而转诊至本单位的617名成年受试者进行了回顾性研究：参与者（72%为男性，70%为肥胖者）进行的睡眠调查报告显示，呼吸暂停-低通气指数（AHI）的总体平均值为 44.0 ± 24.8 事件-h-1。总体而言，66% 的患者被归类为严重 OSA，76% 的患者出现夜间低氧血症。通过分析 OSA 严重程度和夜间低氧血症对合并症风险的影响，多变量分析强调了年龄和肥胖的主要作用。因此，在将年龄较大和肥胖的参与者排除在分析之外后，我们注意到严重 OSA 与高血压（几率比（OR）= 3.0 [95% 置信区间 [CI]1.4-6.2]，P = 0.004）和夜间低氧血症（OR = 2.6 [95% CI 1.2-5.4]，P = 0.01）的风险有关：这项研究似乎表明，在非肥胖的年轻受试者中，OSA 是高血压发病风险的一个易感因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Glasgow Mathematical Journal 数学-数学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Glasgow Mathematical Journal publishes original research papers in any branch of pure and applied mathematics. An international journal, its policy is to feature a wide variety of research areas, which in recent issues have included ring theory, group theory, functional analysis, combinatorics, differential equations, differential geometry, number theory, algebraic topology, and the application of such methods in applied mathematics. The journal has a web-based submission system for articles. For details of how to to upload your paper see GMJ - Online Submission Guidelines or go directly to the submission site.