ANTIBACTERIAL ACTIVITY OF EGGPLANT ETHYL ACETATE EXTRACT (Solanum melongena L.) AGAINST Escherichia coli

Medical and Health Science Journal Pub Date : 2023-02-14 DOI:10.20884/1.mhj.2023.2.2.8053

Miranti Handayani, Setiawati Setiawati, Nia Krisniawati, E. Sutrisna

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Abstract

Purple eggplant have methanol, flavonoids, saponins, and tannins compounds which have potential as antibacterial. Escherichia coli (E. coli) is one of the germs that cause various kinds of infections and currently many are reported to have experienced resistance to a number of conventional antibiotics. The purpose of this study was to explore the antibacterial activity of purple eggplant ethyl acetate extract against Escherichia coli (E. coli) bacteria. This research is an experimental study using the microdilution method to determine the minimum inhibitory concentration (MIC) and the spread-plate method to determine the minimum bactericidal concentration (MBC). This study used various doses of purple eggplant ethyl acetate extract (5-40 mg/mL) as the treatment group and the control group that was not given purple eggplant ethyl acetate extract. Purple eggplant ethyl acetate extract has a MIC value of 20 mg/mL and a MIC value of 20 mg/mL. The percentage of inhibition of purple eggplant ethyl acetate extract against E. coli bacteria was greater with the higher concentration used. Purple eggplant ethyl acetate extract has potential as a antibacterial against E. coli

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茄乙酸乙酯提取物的抑菌活性研究对抗大肠杆菌

紫茄子含有甲醇、类黄酮、皂苷和单宁化合物，具有潜在的抗菌作用。大肠杆菌(E. coli)是引起各种感染的细菌之一，目前据报道，许多细菌对许多常规抗生素产生了耐药性。本研究旨在探讨紫茄子乙酸乙酯提取物对大肠杆菌的抑菌活性。本研究是采用微量稀释法测定最小抑菌浓度(MIC)和铺板法测定最小杀菌浓度(MBC)的实验研究。本研究采用不同剂量紫茄乙酸乙酯提取物(5 ~ 40 mg/mL)作为治疗组，不给予紫茄乙酸乙酯提取物的对照组。紫茄子乙酸乙酯提取物的MIC值为20 mg/mL, MIC值为20 mg/mL。紫茄子乙酸乙酯提取物对大肠杆菌的抑菌率随浓度的增加而增加。紫茄子乙酸乙酯提取物对大肠杆菌具有潜在的抗菌作用

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Medical and Health Science Journal

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